نتایج جستجو برای: organoplatinum
تعداد نتایج: 68 فیلتر نتایج به سال:
Control over structural transformations in supramolecular entities by external stimuli is critical for the development of adaptable and functional soft materials. Herein, we have designed and synthesized a dipyridyl donor containing a central Z-configured stiff-stilbene unit that self-assembles in the presence of two 180° di-Pt(II) acceptors to produce size-controllable discrete organoplatinum(...
Human type II topoisomerase (Top2) isoforms, hTop2α and hTop2β, are targeted by some of the most successful anticancer drugs. These drugs induce Top2-mediated DNA cleavage to trigger cell-death pathways. The potency of these drugs correlates positively with their efficacy in stabilizing the enzyme-mediated DNA breaks. Structural analysis of hTop2α and hTop2β revealed the presence of methionine ...
Carbon nanotubes have unique properties like high stability, high surface to mass ratio and so on which make them suitable for medicinal purpose applications. Treatment of cancer by organoplatinum agents like Cisplatin has become unresponsive in most cases due to low distribution of drug in biological fluids, inability of drug to cross cellular membranes and low stability in biological environm...
Title of Document: LIGAND-ENABLED PLATINUM—CARBON BOND FUNCTIONALIZATION UTILIZING DIOXYGEN AS THE TERMINAL OXIDANT Julia Khusnutdinova, Doctor of Philosophy, 2009 Directed By: Assistant Professor Andrei N. Vedernikov, Department of Chemistry and Biochemistry The use of organotransition metal complexes for selective functionalization of hydrocarbons is of great importance. Dioxygen is the most ...
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