BACKGROUND Oral cavity squamous cell carcinoma (OSCC) is one of the most common cancers worldwide, and its incidence is still increasing. Approximately 50% of patients with OSCC die within 5 years after diagnosis, mostly ascribed to the fact that the majority of patients present advanced stages of OSCC at the time of diagnosis. METHODS To discover salivary biomarkers for ameliorating the dete...

The most common malignancy of the head and neck region is “oral squamous cell carcinoma” (OSCC) because its low survival rate increasing incidence in some geographic areas. The process invasion metastasis, which noted cancers, requires loss cell-to-cell attachment. It therefore important to identify a marker that would help identification lesions acquire ability transform into OSCC. Cell...

The contactin 1 (CNTN1) gene exerts oncogene‑like activities and its expression has been linked to several human malignancies. In this study, a possible association between CNTN1 expression and clinicopathological parameters and clinical outcomes in patients with oral squamous cell carcinoma (OSCC) was examined. CNTN1 protein expression was evaluated by immunohistochemistry in OSCC tissues of 4...

PURPOSE To probe the role of FasL in cell apoptosis in oral squamous cell carcinomas (OSCCs). METHODS The expression of Fas/FasL was assessed in 10 cases of normal oral epithelium, 38 cases of OSCC and tumor infiltrating lymphocytes (TIL), and 11 cases of metastatic lymph nodes by immunohistochemistry. Apoptosis of tumor cells and TIL was detected by terminal deoxynucleotidyl transferase-medi...

BACKGROUND/AIMS SMAD7 is a key inhibitor of transforming growth factor β (TGFβ) receptor signaling, which regulates the alteration of cancer cell invasiveness through epithelial-mesenchymal cell conversion. Dysfunction of protein ubiquitination plays a critical role in carcinogenesis, whereas the involvement a deubiquitinating enzyme, cylindromatosis gene (CYLD), in the tumor invasion of oral s...

Introduction:Oral Squamous Cell Carcinoma (OSCC) is an invasive neoplasm with a high prevalence. Matrix Metalloproteinase (MMP) has been thought to play an important role in both the invasion and metastasis of tumors. The aim of this study was to explore the significance of MMPs expression in clinical outcome of these patients. Materials:The most recognized data Bases such as PubMed, Google sc...

Background: The decisive etiology of Oral squamous cell carcinoma (OSCC)  is still ambiguous, but we recognize the contribution of genetic aberration and environmental agent due to OSCC initiation. In the current study, we elucidate the potential impact of EGFR gene polymorphisms in the risk of OSCC in the southeast of Iran. Methods: Forty-eight OSCC patients along with 100 normal volunteers w...

Oral cavity squamous cell carcinoma (OSCC) is a leading cause of cancer-related deaths worldwide and associated with poor prognosis and mortality. Discovery of proteins that can improve OSCC treatment is needed. Using comparative proteome profiling of primary cells derived from OSCC and adjacent noncancerous epithelium, endoplasmic reticulum aminopeptidases 2 (ERAP2) has been identified as an O...

Oesophageal cancer (OC) is the seventh most common malignancy worldwide, and there are few effective treatment options for advanced OC. Fluoropyrimidine platinum-based chemotherapy has been standard first-line oesophageal squamous cell carcinoma (OSCC) but survival outcomes poor. Therefore, a need to develop new, more drugs. Immune checkpoint inhibitors (ICIs) have emerged as new several malign...

BACKGROUND Dysregulation of miR-9 is a common feature of many types of cancers, including oral squamous cell carcinoma (OSCC). However, whether the expression level of serum miR-9 is changed in patients with OSCC remains unknown. MATERIAL/METHODS Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to examine the expression level of serum miR-9 in OSCC patients, oral leuko...