The ability of Gram-negative bacteria to carefully modulate outer membrane (OM) composition is essential to their survival. However, the asymmetric and heterogeneous structure of the Gram-negative OM poses unique challenges to the cell's successful adaption to rapid environmental transitions. Although mechanisms to recycle and degrade OM phospholipid material exist, there is no known mechanism ...

Pharmaceutical approaches based on nanotechnologies and the development of eye drops composed of the mucoadhesive polymers chitosan and hyaluronic acid are emerging strategies for the efficient treatment of ocular diseases. These innovative nanoparticulate systems aim to increase drugs' bioavailability at the ocular surface. For the successful development of these systems, the evaluation of muc...

bioedegradable nanoparticles are intensively investigated for their potential applications in drug delivery systems. being a biocompatible and biodegradable polymer, chitosan holds great promise for use in this area. this investigation was concerned with determination and optimization of the effective parameters involved in the production of chitosan nanoparticles using ionic gelation method. s...

Respiratory Syncytial Virus (RSV) is one of the most common causes of severe respiratory tract infections worldwide. An effective RSV vaccine requires the induction of mucosal immunity which is a major hurdle. Development of polymeric nanoparticle delivery systems is one of the strategies to overcome this hurdle. PLGA, a biodegradable copolymer is FDA approved and chitosan, a mucoadhesive polym...

Chitosan has gained increasing interest for siRNA delivery. Although chitosan covers a family of structurally different polysaccharides, most siRNA delivery studies have been performed with conventional partially N-acetylated chitosans. Herein, the purpose was to identify fundamental chitosan molecular properties favoring siRNA delivery and efficient gene silencing in mammalian cells. Nanoparti...