…………………………………………………………………………………… 8 1 INTRODUCTION …………………………………………………………………………… 10 2 REVIEW OF THE LITERATURE ………………………………………………………… 12 2.1 The Eye ………………………………………………………………………………… 12 2.2 Blood Circulation in the Eye …………………………………………………………… 12 2.2.1 Regulation of Blood Circulation ………………………………………………… 13 2.3 Aqueous Humour Dynamics and Intraocular Pressure ………………………………… 14 2.4 Glaucoma …………………………...

The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are expressed in pacemaker cells very early during cardiogenesis. This work aimed at determining to what extent these channels are implicated in the electromechanical disturbances induced by a transient oxygen lack which may occur in utero. Spontaneously beating hearts or isolated ventricles and outflow tracts dissected from...

PURPOSE To compare the baseline aqueous humor dynamics in white Caucasians and patients of African origin with previously untreated primary open-angle glaucoma (POAG) or ocular hypertension (OHT). METHODS Ninety-one participants were enrolled in this prospective, observational controlled study: 34 black subjects with POAG or OHT, 32 white Caucasian participants with POAG or OHT, and 12 black ...

Context. Previous numerical studies have shown that in protostellar outflows, the outflowing gas mass per unit velocity, or mass–velocity distribution m ( v ), can be well described by a broken power law ∝ − γ . On other hand, recent observations of sample outflows at various stages evolution show CO intensity–velocity distribution, closely related to follows an exponential exp(− ∕ 0 ). Aims. I...

Background Left ventricular (LV) and right ventricular (RV) systolic performance, typically measured as the ejection fraction (EF), is strongly correlated with mortality. However, CMR provides multiple measures that may also reflect systolic performance including LV volumes and cardiac outflow. We examined the predictive relationship of multiple potential measures of cardiac systolic performanc...

We present a case of an 18-year-old boy with neurofibromatosis type 1 and hypertrophic cardiomyopathy with systolic anteward movement of the anterior leaflet of the mitral valve. Gradient in the left ventricular outflow was 85 mm Hg secondary to subvalvular aortic stenosis with left ventricular diastolic dysfunction. The possibility of a coincidence, or a causal relationship of these 2 conditio...

AIMS Atrial and brain natriuretic peptide levels closely reflect impaired left ventricular function in patients with heart failure. In the present study we assessed the determinants and the clinical significance of atrial and brain natriuretic peptide plasma levels in hypertrophic cardiomyopathy. METHODS AND RESULTS In 44 patients with hypertrophic cardiomyopathy (40+/-15 years) we evaluated:...

Vertebrate cardiac progenitor cells are initially allocated in two distinct domains, the first and second heart fields. It has been demonstrated that first heart field cells give rise to the myocardial cells in the left ventricle and part of the atria, whereas second heart field cells move into the developing heart tube and contribute to the myocardium of the outflow tract and right ventricle a...