Background: Slipped-DNAs are mutagenic intermediates in disease-causing trinucleotide repeat instability; their processing is not well understood. Results: MutLα is required to repair single short slip-outs, and enhances repair of clustered slipouts. Conclusion: Aberrant mismatch repair attempts on clustered slip-outs may cause repeat instability. Significance: This work has determined one of t...

The management of IT carve-out projects is very challenging due to the strict time frame, the severe contractual penalties, the huge number of stakeholders and the various as well as unique IT tasks that have to be conducted. Up to now, there is no instrument for evaluating the readiness of the IT for a carve-out and also not for managing such a project. In order to address this, we develop a m...

This paper proposes a rule to determine the winner of a soccer match which is different from the traditional penalty shoot-outs at the end of extra time. We show that games can be more attractive if penalties are shot before extra time and the outcome counts only if the tie is preserved during extra time. In general, this rule will promote offense by the team that loses the penalty shoot-outs a...