BACKGROUND AND OBJECTIVE To explore whether reflectance spectroscopy can differentiate normal ovary, benign neoplasms, and ovarian cancer. STUDY DESIGN/MATERIALS AND METHODS Reflectance spectra (390-600 nm) were measured at three source-detector separations (SDS) in vivo at 64 sites in 16 patients undergoing oophorectomy. Parameters with largest statistical differences were identified. Based ...

PURPOSE The cancer-testis (CT) family of antigens is expressed in a variety of malignant neoplasms and is silent in normal tissues, except for the testis. Expression of two members of this family, MAGE-A4 and NY-ESO-1, has been described in melanomas, germ cell tumors, certain carcinomas and sarcomas, and more recently in uterine neoplasms. The objective of this study was to evaluate the extent...

Background: Alpha-smooth muscle actin (α-SMA) is an isoform of actin, positive in myofibroblasts and is an epithelial to mesenchymal transition (EMT) marker. EMT is a process by which tumor cells develop to be more hostile and able to metastasize. Progression of tumor cells is always followed by cell composition and extracellular matrix component alteration. Increased α-SMA expression and colla...

Background: Heparanase and endothelin-1/endothelin A receptor (ET-1/ETAR) expressions increase in cancer. This condition enhances tumor progression and correlates with poor survival. Limited data are documented regarding the role of heparanase and ET-1/ETAR in epithelial ovarian cancer (EOC). We sought to characterize the correlation between heparanase and ET-1/ETAR in EOC.Methods: Thirty patie...

Ovaries are paired structures with an embryological, anatomic and functional complexity. Changes in their volume can be observed at ovulation, pregnancy and after menopause. Ovaries are normally resistant to diseases, but still ovary can be seat of more number of neoplastic lesions of benign and malignant. They may be primary or secondary, large or small, solid or cystic and also of mixed patte...

Fibrothecomas are sex-cord stromal tumors that have histologic appearances intermediate between fibromas and thecomas. The exact incidence of fibrothecoma is unknown, although they have been described as rare ovarian neoplasms. A 69 year old post menopausal female was presented with a huge left ovarian mass (17x15x8 cm). Intraoperative scrape smears were prepared from the ovarian mass. Smears s...

Background: Ovarian masses requiring surgical intervention are uncommon in the pediatric population. The aim of this study was to report results of a multicentric Tunisian study concerning the clinical practice and the management of pediatric ovarian masses and to identify the factors that are associated with ovarian preservation. Materials and Methods: Between January 2000 and December 2015...

Epithelial ovarian carcinoma (EOC) is the fourth leading cause of cancer mortality among women in western countries. The incidence of newly diagnosed EOC in the US is estimated to be 22,430 cases per year with 15,280 deaths (Jamel A et al., 2006). Surface epithelial-stromal tumors are the most common neoplasms of the ovary. Their origin is likely the epithelium lining the ovarian surface and/or...

Background: The ovarian neoplasms are the cause of highest mortality in female genital tract. Histomorphological study is the gold standard to assess the treatment modalities and prognosis of various tumors. Aim: This study is done to determine the age incidence, prevalence and morphological variants of ovarian neoplasms Materials and methods: This is retrospective and prospective study done fr...

Ovarian sex cord stromal tumor is a relatively rare subtype of ovarian neoplasms, consisting of only 8% of all primary ovarian neoplasms, among which sex cord tumor with annular tubules (SCTAT) accounts for only 6% of sex cord stromal tumors. The majority of patients with SCTAT are women at reproductive age. Roughly one-third of the patients have Peutz-Jeghers syndrome (PJS), and in cases witho...