Obesity in women is increased by the loss of circulating estrogen after menopause. Shift work, which disrupts circadian rhythms, also increases the risk for obesity. It is not known whether ovarian hormones interact with the circadian system to protect females from obesity. During high-fat feeding, male C57BL/6J mice develop profound obesity and disruption of daily rhythms. Since C57BL/6J femal...

OBJECTIVE The aim of the present study was to evaluate the effects of ovariectomy on the secretory apparatus of natriuretic peptides in right atrial cardiomyocytes. METHODS Nine-month-old mice underwent bilateral ovariectomy or sham surgery. The blood exam of the ovariectomized mice showed results consistent with castrated females. Systolic blood pressure was measured after ovariectomy (9 mo ...

Abstract Background and Aims The pathogenesis of obesity related-renal disease is unknown. Gender differences may have a role in renal damage obesity. In particular, menopause can promote obese women. previous study we observed that male female mice developed albuminuria, hyperfiltration glomerulomegaly, these changes were more severe those ovariectomized females. this evaluated inflammation li...

We investigated whether object recognition memory is modulated by estrogen in young (5 month) and aged (24 month) female C57Bl/6J mice, and if cholinergic muscarinic receptors might contribute to this response. Mice that were ovariectomized, or ovariectomized plus estradiol-treated three weeks before behavioral testing or quantitative autoradiography were compared to intact mice. Memory for a p...

Abstract Background Macrophages and inflammatory cytokines play important roles in bone fracture healing. However, the expression patterns of macrophages during healing under condition postmenopausal osteoporosis have not been fully revealed. Methods Tibia transverse was established 12 weeks after ovariectomy or sham operation 16-week old female mice. Tibias were harvested before 1, 3, 5, 7, 14...

BACKGROUND Lepidium meyenii, known as Maca, grows exclusively in the Peruvian Andes over 4000 m altitude. It has been used traditionally to increase fertility. Previous scientific studies have demonstrated that Maca increases spermatogenesis and epididymal sperm count. The present study was aimed to investigate the effects of Maca on several fertility parameters of female mice at reproductive a...

background: the fracture healing is impaired in osteoporosis. piper sarmentosum is a plant, which contains potent antioxidant, naringenin that may enhance fracture healing. the present histological study aimed to determine the effects of water extract of piper sarmentosum on the late phase of fracture healing in estrogen-deficient rats. methods: twenty four female sprague-dawley rats (200-250 g...

Estrogens are known to modulate lower urinary tract (LUT) trophicity and neuronal nitric oxide synthase (nNOS) expression in several organs. The aim of this study was to explore the effects of endogenous and supraestrus levels of 17beta-estradiol (E2) on LUT and urethral nNOS expression and function. LUT function and histology and urethral nNOS expression were studied in adult female mice subje...

This study tested the hypothesis that estrogen enhances axonal sprouting in the hippocampal formation in the female mouse. The entorhinal cortex was unilaterally lesioned with ibotenic acid in control mice and in ovariectomized mice that were treated with a high dose of, a moderate dose of, or zero estrogen supplementation pellets. Four weeks later the density of staining for synaptophysin immu...