The relationship between obesity and renal lesions, especially in low estrogen levels, has been less documented. The aim of this study was to assess the renal changes in diet-induced obesity in ovariectomized rats. Wistar rats were ovariectomized or sham-operated and divided into four groups: sham-operated rats fed a standard diet (SSD); ovariectomized rats fed a standard diet (OSD); sham-opera...

Objective- This study was designed to determine the effect of pomegranate seed oil (PSO) treatment on oxidative stress and lipid profiles in ovariectomized (OVX) rats. Design- Experimental study Animals- 24 female Wistar rats Procedures-The rats were randomly divided into four groups: sham-operated (SHAM), SHAM with PSO treatment (SHAM + PSO), ovariectomized (OVX), and ovariectomized with PSO t...

Prevalence of metabolic syndrome and progression of nephropathy depend on sex. We examined a protective effect of estradiol against nephropathy in metabolic syndrome through the modulation of the arachidonic acid metabolism by activating the 5-lipoxygenase and cytochrome p450 4A pathways. 28 female Wistar rats were divided into four groups of seven animals each: control, intact metabolic syndro...

Grewal, Michelle, Janis Cuevas, Gautam Chaudhuri, and Lauren Nathan. Effects of calcitonin gene-related peptide on vascular resistance in rats: role of sex steroids. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H2063–H2068, 1999.—It has been demonstrated in reflex-intact animals that the sensitivity to calcitonin gene-related peptide (CGRP) is increased during pregnancy and that this action i...

Cows' milk contains considerable quantities of estrogens, mainly in the form of estrone sulfate (ES). To determine whether the commercial milk has any biologically significant hormonal effects, 2 series of uterotrophic tests were performed, 1 with young ovariectomized rats and the other with sexually immature rats. Thirty-six rats were used for each test. They were divided into 3 groups of 12 a...

When conducting vaginal irritation studies, ovariectomized rats or rabbits are typically used according to practical reports. In the present study, we evaluated the influence of the estrus cycle in a vaginal irritation study using intact rats and ovariectomized rats, which exhibit a late diestrus-like condition, to determine whether intact rats can be useful for evaluating vaginal irritancy. Ra...

OBJECT The authors studied the effect of gender and hormonal status on survival in nude rats implanted with human glioblastoma multiforme (GBM) cell lines. METHODS Nude rats received intracerebral implants of either wild-type U87MG cells or U87MG cells transfected with the gene for endothelin-1 (U87/ET-1). In the initial study, survival was compared in males and females for each of the two ce...

Background and Aim: Cessation of ovarian function is a major cause postmenopausal osteoporosis. Ovariectomized rats dogs have been used extensively in osteoporosis models. This study examined the effect Pueraria Radix isoflavone extract not only on Bone Mineral Density (BMD) but also bone strength using formation resorption markers ovariectomized as an model. Methods: The model (OVX) induced by...

Retinol is a commonly used vitamin, especially by elderly people. Alendronate sodium, an aminobisphosphonate, is a potent antiresorptive drug used in the treatment of osteoporosis in postmenopausal women. Frequently, alendronate sodium and retinol are used concurrently. There are no reports on the interaction between alendronate sodium and retinol. The aim of the present study was to investigat...

The aim of this study was to observe the effects of jujube on learning and memory in ovariectomized rats. The effects of jujube on learning and memory in ovariectomized rats were observed using the Morris water maze method. The serum follicle-stimulating hormone (FSH), estrogen and luteinizing hormone (LH) levels, and the brain nitric oxide synthase (NOS) and acetylcholinesterase (AChE) levels ...