STUDY QUESTION How do apoptosis-related BCL2 and BAX genes, known to regulate death or survival of germ cells in fetal and adult life, and germ-cell-specific VASA protein behave from birth to puberty in the human ovary? SUMMARY ANSWER In resting primordial follicles in both infant and pubertal ovaries, BCL2 family members and germ-cell-specific VASA behave as in fetal life. After birth, once ...

The measurement of ovarian volume has been recently shown to predict follicular response in in-vitro fertilization (IVF), specifically a lower number of retrieved oocytes with decreasing ovarian volume. This test appears to be better than basal follicle-stimulating hormone (FSH) as a prognostic measure of ovarian reserve. However, the effect of pituitary desensitization on ovarian volume has no...

Anti-Müllerian hormone (AMH) is a homodimeric glycoprotein, a member of the transforming growth factor-β superfamily. Over the last decade, a large number of studies examining the multiple roles of AMH have been published. AMH levels accurately reflect the ovarian follicular reserve and could, therefore, be considered as an extremely sensitive marker of ovarian aging and a valuable tool in the ...

To better understand possible effects of bisphenol A (BPA) exposure on ovarian reserve in women with polycystic ovary syndrome (PCOS), we measured creatinine adjusted urinary BPA (BPA_Cre) concentrations and used regression models to evaluate the association between urinary BPA level and antral follicle count (AFC), antimullerian hormone (AMH), day-3 follicle stimulating hormone levels (FSH) an...

Background: Polycystic ovary syndrome (PCOS) is one of the main factors leading to infertility and ovulatory dysfunction in women. The aim current research study levels Inhibin A B women with PCOS, depending on level Anti-millerian hormone. Materials methods: 30 infertile (I group) PCOS (excluding hyperprolactenemia, hypothyreosis, autoimmune thyroiditis) healthy (II were involved study. Hormon...

Aim To clarify the effects of small endometriomas on in vitro fertilization (IVF) outcomes. In the present study, the potential impact of small ovarian endometriomas on the quantitative and qualitative outcomes of IVF was evaluated in the same individual. Methods A retrospective analysis was performed, in which 118 infertile women with unilateral endometriomas that were <40 mm in size and who...

BACKGROUND Residual ovarian function after laparoscopic excision of endometriotic ovarian cysts is a major and still unsolved topic. Ultrasonographic evaluation of ovarian response to ovulation stimulation represents a simple yet poorly employed tool to assess residual ovarian function after surgery. METHODS Data from patients referred for IVF or ICSI between January 2001 and December 2002 we...

Background: Polycystic ovary syndrome (PCOS) is defined using the Rotterdam criteria. PCOS affects 5%–15% of females reproductive age and first cause infertility due to anovulation. The aim this work was predict success laparoscopic ovarian drilling (LOD) or redrilling in PCOS. Methods: This observational study carried out on 50 female cases childbearing with BMI range from 18-28Kg/m2, > 3 year...

The ovary contains oocytes within immature (primordial) follicles that are fixed in number at birth. Activation of follicles within this fixed pool causes an irreversible decline in reproductive capacity, known as the ovarian reserve, until menopause. Premenopausal women undergoing commonly used genotoxic (DNA-damaging) chemotherapy experience an accelerated loss of the ovarian reserve, leading...