Many decades of research have produced a significant amount of data showing increased oxidative stress in asthma and indicating a potential role for oxidants in the pathogenesis of the disease, particularly during exacerbations. Putatively relevant pro-oxidative mechanisms have also been identified. Currently available asthma drugs are generally effective for the treatment of the disease, but t...

OBJECTIVE In chronic hemodialyzed (CH) patients the balance between production of reactive oxygen species and antioxidant defense system is disturbed and shifted towards oxidative conditions. The properties of albumin in CH patients were studied before hemodialysis (HD) and post-HD. METHODS Two oxidants were applied, organic t-butyl hydroperoxide (t-BOOH) and inorganic hydroperoxide (H2O2), f...

Oxidative stress mediated by pro-oxidants has been implicated in the pathogenesis of vascular disorders. However, the effect of pro-oxidants on myogenic regulation of vascular function and the differential influence of gender is not known. Superoxide dismutase (SOD), an intracellular enzyme restricts excess pro-oxidant levels and may limit vascular dysfunction. We therefore tested the effects o...

Oxidative burst provides the mechanism for specialized phagocytes, such as granulocytes or monocytes, to kill invading microorganisms through generation of superoxide anions. However, the oxidants generated during the burst damage DNA of the phagocytes and neighboring cells. Human blood leukocytes treated with phorbol myristate acetate (PMA) are considered to represent the experimental model of...

Insulin resistance and abdominal obesity are present in the majority of people with the metabolic syndrome. Antioxidant therapy might be a useful strategy for type 2 diabetes and other insulin-resistant states. The combination of vitamin C (Vc) and vitamin E has synthetic scavenging effect on free radicals and inhibition effect on lipid peroxidation. However, there are few studies about how to ...

We have analyzed the transcription organization of ahpC, ahpF, oxyR, and orfX from Xanthomonas campestris pv. phaseoli. ahpC was transcribed as a monocistronic 0.6-kb mRNA, while ahpF-oxyR-orfX were transcribed as a polycistronic approximately 3.0-kb-long mRNA. The novel transcription organization of these genes has not observed in other bacteria. Western analysis showed that oxidants (peroxide...

As the largest organ in human body, skin should be protected from various harmful chemicals and pollutants surrounding environment ultraviolet (UVA/UVB) radiation emitted sunlight. This has prompted formulation scientists to embark on new technology formulate cosmetics free of synthetic using natural plant-based extracts as replacement. Natural phytoanti-oxidants, viz. catechin, quercetin galli...

The imbalance in to oxidants and antioxidants leads to the condition called oxidative stress. The oxidative stress is considered as one of the etiopathological factors for development and /or exacerbation of psoriasis. Therefore we undertook this study to determine serum levels of oxidants (Malondialdehyde MDA, Nitric oxide NO) and antioxidants (Total Antioxidant Status TAS, Superoxide Dismutas...

boiling of water for its purification has been recommended since 500 b. o. modern desinfecition methods involve specialized treatments for the purpose of destroying or inactivating pathogenic organisms . different factors .in flu - ensing the efficiency of desinfection are considered in this article physical and chemical methods of water desinfection are described briefly the use of chemical ox...

Oxidants are highly unstable molecules that attack every chemical substance they come into contact. Oxidants modify the macromolecules both structurally and functionally. Body has defense mechanisms against oxidants in the form of both enzymatic and non-enzymatic antioxidants. Reactive oxygen species (ROS) are a group of oxidants formed during oxygen metabolism. ROS appears to be involved in th...