نتایج جستجو برای: oxymorphone
تعداد نتایج: 168 فیلتر نتایج به سال:
On January 23, 2015, the Indiana State Department of Health (ISDH) began an ongoing investigation of an outbreak of human immunodeficiency virus (HIV) infection, after Indiana disease intervention specialists reported 11 confirmed HIV cases traced to a rural county in southeastern Indiana. Historically, fewer than five cases of HIV infection have been reported annually in this county. The major...
A procedure for the simultaneous confirmation of codeine, morphine, 6-acetylmorphine, hydrocodone, hydromorphone, oxycodone, and oxymorphone in urine specimens by gas chromatography-mass spectrometry (GC-MS) is described. After the addition of nalorphine and naltrexone as the two internal standards, the urine is hydrolyzed overnight with beta-glucuronidase from E. coli. The urine is adjusted to...
The C-3 phenolic hydroxy group containing morphine derivatives (morphine, oxymorphone, naloxone, naltrexone) are excellent candidates for the synthesis of 3-O-functionalized molecules. Achieving free carboxylic gives opportunity further modification and conjugation that could be used immunization immunoassays. For this purpose ethyl bromo- chloroacetate can as O-alkylating agents. Hydrolyzing p...
Further investigations into the molecular actions of the 14-hydroxydihydromorphinone hydrazones (naloxazone, oxymorphazone, and naltrexazone) have suggested that their irreversible actions can be explained by the formation of their azines. These azines, naloxonazine, naltrexonazine, and oxymorphonazine, irreversibly block opiate binding in vitro 20- to 40-fold more potently than their correspon...
AIM A systematic review of chronic pain treatment with strong opioids (step 3 WHO pain ladder) and a comparison to a new drug recently approved for the treatment of severe chronic pain in Europe, tapentadol (Palexia, Nucynta*), were performed. METHODS Thirteen electronic databases were searched as well as a number of other sources from 1980 up to November 2010 for relevant randomized controll...
Sadiq, M. W. 2012. In Vivo Active Drug Uptake and Efflux at the Blood-Brain Barrier: With Focus on Drug Transport Interactions. Acta Universitatis Upsaliensis. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy 165. 50 pp. Uppsala. ISBN 978-91-554-8472-9. The blood-brain barrier (BBB) controls the movement of substances into and out of the brain. The tight jun...
Morphinans play an important role among therapeutically valuable opioids. They include powerful pain relieving agents such as naturally occurring alkaloids (e.g. morphine, codeine), semisynthetic derivatives (e.g. oxycodone, oxymorphone, buprenorphine), and synthetic analogues (e.g. levorphanol, butorphanol). These opioid drugs produce their biological actions through three receptor types, μ, δ...
Thrombotic microangiopathy (TMA) associated with injecting sustained-release oxymorphone, an opioid intended for oral use, has previously been reported. We report a case of TMA secondary to intravenous use of sustained-release oxycodone, and the first case to demonstrate relapsing disease due to persistent intravenous opioid use. In cases such as these, TMA is suspected to be due to a polyethyl...
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