Postpartum haemorrhage (PPH) is one of the most important causes of maternal mortality in developing countries. A consensus was reached on active management of the third stage of labour for all parturients especially for those for whom the access to hospital services is difficult or time-consuming. Oral (methyl)ergometrine was considered to be a possible alternative prophylactic oxytocic, that ...

The direct regulation of testis androgen and progestin biosynthesis by neurohypophysial hormones was investigated in a primary culture of rat testis cells. Treatment with arginine vasotocin (AVT; 10(-6) M) over a 10-day period inhibited the human chorionic gonadotropin (hCG)-stimulated testosterone accumulation while enhancing hCG-stimulated progesterone accumulation. Furthermore, treatment wit...

Analogues of Wysine-vasopressin in which the carboxamide groups on the glutamine and asparagine residues at positions 4 and 5 are replaced individually by hydrogen have been synthesized by the p-nitrophenyl ester method of peptide synthesis and tested for some of the pharmacological activities characteristic of this pressor-antidiuretic hormone of the posterior pituitary gland. The 4-decarboxam...

Postpartum haemorrhage (PPH) still remains one of the primary causes maternal mortality throughout planet. Prompt management PPH with medical and surgical intervention should be encouraged as it can lifesaving. Primary methods include a simple bi-manual compression, oxytocic drugs such oxytocin, ergometrine, prostaglandins these are safe effective, but occasionally prove inadequate or unsatisfa...

If the excised, parturient rabbit uterus is repeatedly treated with a Krebs solution free from Ca, its tension in a tetanus drops gradually, and in 15 to 30 minutes becomes zero. We call such a uterus "Ca-deficient." The uterus in this condition has a high threshold, it is non-propagating, "inexcitable," fails to respond to oxytocics in a characteristic fashion, but retains maximum contractilit...