Elevated in vivo markers of presynaptic striatal dopamine activity have been a consistent finding in schizophrenia, and include a large effect size elevation in dopamine synthesis capacity. However, it is not known if the dopaminergic dysfunction is limited to the striatal terminals of dopamine neurons, or is also evident in the dopamine neuron cell bodies, which mostly originate in the substan...

The most significant pathological feature of Parkinson's disease (PD) is the progressive degeneration of dopaminergic (DA) neurons in the substantia nigra. Currently, available treatments for PD cannot prevent the loss of DA neurons. Tyrosine hydroxylase (TH) expressed in substantia nigra neurons catalyzes the conversion of tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA), which is the rate-li...

We assessed the effects of ambient tropospheric ozone on annual tree-ring growth, delta(13)C in the rings, leaf gas exchange and visible injury in three ozone-sensitive woody plant species in southern Switzerland. Seedlings of Populus nigra L., Viburnum lantana L. and Fraxinus excelsior L. were exposed to charcoal-filtered air (CF) and non-filtered air (NF) in open-top chambers, and to ambient ...

this study was carried out to investigate the important characteristics in some cultivars/genotypes of persianwalnut (juglans regia l.), black walnut (j. nigra l.), and walnut inter-specific hybrids: paradox (j. hindsii × j.regia) and royal (j. hindsii × j. nigra) in kamalshahr research station in karaj in 2011-2012. in the study,vegetative vigor was evaluated based on trunk cross-sectional are...

susceptibility maps obtained with the CF solution (Rho = 0.94, r = 0.97) on the regions of interest, GP -globus pallidus, SN susbtantia nigra, C caudate, RN red nucleus, P putamen, FM forceps major, IFOF inferior fronto-occipital fasciculus Fig. 1 shows error of QSM maps in respect to Ground Truth (zero being lowest reconstruction error) as a function of the regularization parameters λ (see Eq....

There is a clear need to develop non-invasive markers of substantia nigra progression in Parkinson's disease. We previously found elevated free-water levels in the substantia nigra for patients with Parkinson's disease compared with controls in single-site and multi-site cohorts. Here, we test the hypotheses that free-water levels in the substantia nigra of Parkinson's disease increase followin...