BACKGROUND The addition of new amino acids to the genetic code of Escherichia coli requires an orthogonal suppressor tRNA that is uniquely acylated with a desired unnatural amino acid by an orthogonal aminoacyl-tRNA synthetase. A tRNA(Tyr)(CUA)-tyrosyl-tRNA synthetase pair imported from Methanococcus jannaschii can be used to generate such a pair. In vivo selections have been developed for sele...

AIMS Calcific uraemic arteriolopathy (CUA) or calciphylaxis is most commonly seen in end-stage renal disease and is associated with significant morbidity and mortality. The aim of this study was to determine whether hyperbaric oxygen therapy (HBOT) is effective in healing calciphylaxis lesions and to determine if there are any patient factors that can predict wound healing and patient survival....

Calciphylaxis, better described as "Calcific uremic arteriolopathy" (CUA), involves about 1-4% of hemodialysis patients all around the world with high mortality rates. We describe a rare clinical case of CUA in peritoneal dialysis patient associated with urological disease. Penile calciphylaxis represents rare clinical complication, and an early diagnosis and multidisciplinary approach are requ...

BACKGROUND Interferon beta-Ia (Avonex) 30 microg, intramuscular (i.m.), once weekly is efficacious in delaying clinically definite multiple sclerosis (CDMS) following a single demyelinating event (SDE). This study determined the cost effectiveness of Avonex compared to current treatment in delaying the onset of CDMS. METHODS A cost-effectiveness analysis (CEA) and cost-utility analysis (CUA) ...

Cua Dai is one of the major estuarine areas in Central Vietnam that plays a significant role in local maritime transport, fisheries, and tourism activities. This paper presents a study that monitored the shoreline dynamics of the Cua Dai estuary over a period of 50 years (1964–2014) by using field survey data, geographic information systems techniques, and multi-temporal satellite remote sensin...

BACKGROUND Traffic calming and speed limits are major public health strategies for further reducing road injuries, especially for vulnerable pedestrians such as children and the elderly. We conducted a cost-benefit analysis (CBA-favoured by transport economists) alongside a cost-utility analysis (CUA-favoured by health economists) of mandatory 20 mph zones, providing a unique opportunity to com...

BACKGROUND AND OBJECTIVES Calcific uraemic arteriolopathy (CUA), also known as calciphylaxis, is a rare but life-threatening condition that almost exclusively affects patients with chronic kidney disease. Several therapies have been employed to treat this disease but with irregular results. We report a prospective case series of eight patients diagnosed with CUA in our unit between 2002 and 201...

A new archaeorthopteran genus and species, Avionugonioneura jouaulti, is described from the Moscovian of Avion in Northern France. It shows several strong similarities, with two genera Contracladus (Pennsylvanian) Nugonioneura (early Permian), viz. a simple vein M emerging anteriorly M+ CuA+CuPa an branched CuA+CuPa, which are putative synapomorphies, suggesting possible attribution to family N...

Sir, Calcific uraemic arteriolopathy (CUA) (‘calciphylaxis’) is a rare necrotizing cutaneous abnormality which is being increasingly recognized in the dialysis population w1x. It is usually associated with secondary hyperparathyroidism in the presence of advanced renal failure and high calciumu phosphate product w2x. Treatment is difficult and often unsuccessful and is associated with a high mo...