Background & Aims: The current study aimed to investigate the role of catastrophizing as mediator variable in the relationship of neuroticism and extraversion with fear of movement and pain intensity in patients with musculoskeletal pain. Methods: This study was conducted on 200 subjects who were selected through purposive sampling from among the clients of Shohada, Emam Hossein, and Sina Hospi...

INTRODUCTION Despite recent advances in anti-inflammatory therapy, rheumatoid arthritis (RA) patients continue to rate pain as a priority. The etiology of RA pain is likely multifactorial, including both inflammatory and non-inflammatory components. In this study, we examine the association between disease activity, sleep, psychiatric distress and pain sensitivity in RA. METHODS Fifty-nine fe...

Background. It seems that based on the independent effects of physical activity and flax oil on pain, it is possible the interactions of these two effects reduces or mitigate the impact of pain or strengthen it. Objectives. This study investigates the effect of high-intensity interval training and flaxseed oil supplementation on hippocampal BDNF expression and pain feeling in male rats. M...

P ain is not something universally enjoyed, especially chronic pain involving nerve damage, referred to as neuropathic pain (1). Pain perception can be modulated in a variety of ways—for example, by focusing attention on the painful stimulus. On page 1168 of this issue, Peng et al. (2) report that pain threshold in dorsal root ganglion neurons (DRG), which relay peripheral sensory information t...

Recent neuroanatomical and behavioral evidence has indicated that vasopressin (VA) increases pain threshold. The dorsal raphe nucleus (DRN) is an important nucleus in pain modulation. Anatomical studies have shown that DRN receives vasopressinergic fibers originating in the hypothalamic paraventricular nucleus. The aim of the present study was to examine the effects of intra-DRN injection of de...

Background: Animals have an internal biological clock with melatonin hormone that helps them to adapt to light/dark circles. Since melatonin is associated with an alteration in the expression and production of opioid receptors, this study aimed to evaluate the effect of changes in the light/dark circles on pain sensation in rats. Methods: This research study in order to investigate the thermal...

UNLABELLED Existing evidence indicates that pain catastrophizing is associated with enhanced pain reports and lower pain threshold/tolerance levels, but is not significantly related to nociceptive flexion reflex (NFR) threshold in healthy and clinical pain samples. This suggests pain catastrophizing may modulate pain threshold at a supraspinal level without influencing descending modulation of ...