As part of natural products or biologically active compounds, the synthesis nitrogen-containing heterocycles is becoming incredibly valuable. Palladium a transition metal that widely utilized as catalyst to facilitate carbon-carbon and carbon-heteroatom coupling; it used in various heterocycles. This review includes twelve years successful indole using palladium catalysts establish carbon-nitro...

Excited-state palladium catalysis is an efficient process for the alkylation of diverse organic compounds via generation alkyl radicals from bromides and iodides. However, more stable chlorides remains challenging. Herein, we demonstrate excited-state palladium-catalyzed synthesis oxindoles isoquinolinediones alkylation/annulation reaction by overcoming inherent limitations associated with unac...

The main catalysts which are traditionally used for the hydrogenation of organic compounds are supported platinum group metals, and while these heterogeneous catalysts are generally not effective in carbon-carbon bond forming reactions, there has been a growing interest in recent years in soluble complexes of the platinum group metals for use as catalysts in organic synthesis. Rhodium catalysed...

The industrially important coupling of aromatic compounds has generally required differential prefunctionalization of the arene coupling partners with a halide and an electropositive group. Here we report that palladium, in conjunction with a copper oxidant, can catalyze the cross-coupling of N-acetylindoles and benzenes in high yield and high regioselectivity across a range of indoles without ...

Broadly applicable palladium-catalyzed heteroarene benzylation reactions are described with a focus on the most challenging heterocyclic classes under traditional benzylation techniques such as sulfur-containing heterocycles and those bearing functional groups that would be incompatible with reactions requiring Lewis acids and/or strong bases.

Several research groups have recently developed methods to employ configurationally stable, enantioenriched organometallic nucleophiles in stereospecific Pd-catalyzed cross-coupling reactions. By establishing the absolute configuration of a chiral alkyltin or alkylboron nucleophile prior to its use in cross-coupling reactions, new stereogenic centers may be rapidly and reliably generated with p...

Abstract In this research, a recycling process for palladium using “dry aqua regia,” which consists of iron(III) chloride–potassium chloride, was proposed. Palladium dissolved in and the recovered by leaching with potassium chloride solution added ammonium nitric acid. almost completely 3 h at 600 K, recovery ratio up to 80%. addition, dissolution coexistence platinum platinum-palladium alloy r...

Palladium-catalyzed direct cross-coupling of aryl chlorides with a wide range of (hetero)aryl lithium compounds is reported. The use of Pd-PEPPSI-IPent or Pd2(dba)3/XPhos as the catalyst allows for the preparation of biaryl and heterobiaryl compounds in high yields under mild conditions (room temperature to 40 °C) with short reaction times.

Abstract The rational design based on a deep understanding of the present reaction mechanism is an important, viable approach to discover new organic transformations. β -Hydrogen elimination from palladium complexes fundamental in catalysis. Normally, eliminated β- hydrogen has be attached sp 3 -carbon. We envision that 2 -carbon possible by using thoroughly designed systems, which may offer st...