OBJECTIVE To assess whether measuring plasma paracetamol concentrations in all patients with drug overdose or collapse (altered consciousness) changes outcome. METHOD A retrospective survey was performed of all patients attending the Accident and Emergency Department at Guy's Hospital, London over a 12 month period who had plasma paracetamol concentrations measured (it is hospital policy that...

OBJECTIVES To compare the management of acute paracetamol poisoning with the best evidence available, and to determine the effect of plasma paracetamol level estimation on the management. DESIGN Descriptive study with an intervention. SETTING Medical wards of the National Hospital of Sri Lanka, Colombo. PATIENTS Patients admitted with a history of acute paracetamol poisoning. INTERVENTI...

paracetamol is a sparingly soluble bitter tasting drug. it is widely used as an analgesic and antipyretic. complexation of drug with different cyclodextrins (?, ? and hp-?-cd) was attempted to improve solubility of paracetamol. during the drug excipient interaction studies, ?, ? cyclodextrins elicited analytical interference and showed considerable absorbance at ?max (243.5 nm) of paracetamol w...

UNLABELLED The use of paracetamol as tool to determine gastric emptying was evaluated in a cross over study. Twelve healthy volunteers were included and each of them consumed two low and two high caloric meals. Paracetamol was mixed with a liquid meal and administered by a nasogastric feeding tube. The post prandial paracetamol plasma concentration time curve in all participants and the paracet...

Paracetamol is a sparingly soluble bitter tasting drug. It is widely used as an analgesic and antipyretic. Complexation of drug with different cyclodextrins (?, ? and HP-?-CD) was attempted to improve solubility of Paracetamol. During the drug excipient interaction studies, ?, ? cyclodextrins elicited analytical interference and showed considerable absorbance at ?max (243.5 nm) of Paracetamol w...

BACKGROUND This study investigated the effect of thiamine pyrophosphate (TPP) on oxidative liver damage induced in rats with high-dose paracetamol. METHODS Rats for this experiment were divided into the following groups: healthy control, paracetamol control, thiamine + paracetamol, TPP + paracetamol, and N-acetylcysteine + paracetamol. Oxidant and antioxidant parameters and liver function tes...

background: according to previous studies there are some different opinions on the pre-emptive effects of paracetamol in controlling post-operative pain, we aimed to compare the analgesic effects of pre-emptive paracetamol with post-operative paracetamol and morphine in patients undergoing septorhinoplasty. materials and methods: a hundred and six patients aged 15 to 50 were divided into 3 grou...

conclusions in the first one hour, diclofenac suppository is able to control the fever more efficient than paracetamol suppositories. results the average rectal temperature in the paracetamol group was 39.6 ± 1.13°c, and 39.82 ± 1.07°c in the diclofenac group (p = 0.37). the average rectal temperature, one hour after the intervention, in the paracetamol and the diclofenac group was 38.39 ± 0.89...

Electrochemical oxidation of paracetamol on boron-doped diamond (BDD) anode has been studied by cyclic voltammetry and preparative electrolysis. Quantification during electrolysis mainly realized differential pulse technique in the Britton-Robinson buffer solutions used as supporting electrolyte. Various parameters such current intensity, nature electrolyte, temperature, initial concentration h...

....................................................................................................................................6 List of original publications ...................................................................................................7 Abbreviations and defi nitions ................................................................................................8 Int...