Paracetamol has a reasonable safety profile when taken in therapeutic doses. However, it could induce hepatotoxicity and even more severe fatal acute hepatic damage when taken in an overdose. The green alga, Dunaliella salina was investigated for hepatoprotective and antioxidant activity against paracetamol-induced liver damage in rats. Male albino Wistar rats overdosed with paracetamol showed ...

Treatment of paracetamol intoxication consists of administration of N-acetylcysteine, preferably shortly after paracetamol ingestion. In most countries, the decision to treat patients with N-acetylcysteine depends on the paracetamol plasma concentration. In the literature, different arguments are given regarding when to treat paracetamol overdose. Some authors do not recommend treatment with N-...

Background: Paracetamol (APAP) is the most famous drug used in the world to relieve of pain and used as an antipyretic. Paracetamol overdose induces liver damage and is a well known hepatotoxic drug. This study was aimed to determine the incidence of acidosis in acetaminophen overdose with the time of NAcetyl Cystiene (NAC) administration and correlation of late acidosis and death in acetaminop...

CONTEXT There is contention over whether reported dose correlates with toxicity in paracetamol poisoning and risk assessment is currently based on serum paracetamol concentration compared to a nomogram, irrespective of reported dose. Objective. To determine if reported dose predicts the need for N-acetylcysteine (NAC). METHODS Data were taken from paracetamol overdoses presenting to a tertiar...