BACKGROUND Ulinastatin (UTI) is a urinary trypsin inhibitor extracted and purified from urine of males. This study aimed to explore the effects of UTI on paraquat-induced-oxidative stress in human type II alveolar epithelial cells. METHODS The human type II alveolar epithelial cells, A549 cells, were cultured in vitro. The A549 cells were treated with different concentrations of paraquat (200...

BACKGROUND Data on the spectrum of corrosive injury to the esophagus after paraquat or glyphosate-surfactant ingestion are sparse in the literature and confined to case studies and brief reports. Therefore, this study aimed to examine the clinical features, degrees of esophageal injury, and clinical outcomes after paraquat or glyphosate herbicide ingestion, and sought to determine what associat...

Paraquat, a fast-acting non-selective contact herbicide, is considered an etiological factor related to Parkinson's disease. This study investigated its effects on hippocampal neurogenesis and cognition in adult mice as well as possible mechanisms for the effects. We administered paraquat (1.25 mg/kg, intraperitoneal injection, i.p.) and an equal volume of normal saline for 3 weeks to adult mal...

Research on eliminating organic pollutants in water by using heterogeneous photocatalysts such as nano-TiO2 abound. However, the question is whether metabolites, resulting from optical dispersion of environmental pollutants, are still toxic to aquatic organisms. Therefore, this study was designed to evaluate the effect of a co-exposure to paraquat and TiO2-NPs on blood biochemical indices of co...

Research on eliminating organic pollutants in water by using heterogeneous photocatalysts such as nano-TiO2 abound. However, the question is whether metabolites, resulting from optical dispersion of environmental pollutants, are still toxic to aquatic organisms. Therefore, this study was designed to evaluate the effect of a co-exposure to paraquat and TiO2-NPs on blood bio...

Environmental exposure to paraquat has been reported to be associated with Parkinson's disease (PD). In experimental animal models paraquat reproduces features of PD, however, the exact mechanism of PD-induced neurotoxicity has not been fully established. This study was designed to investigate paraquat-mediated interference with mitochondrial function and autophagy, and determine the impact of ...

Lung injury is the main manifestation of paraquat poisoning. Few studies have addressed brain damage after paraquat poisoning. Ulinastatin is a protease inhibitor that can effectively stabilize lysosomal membranes, prevent cell damage, and reduce the production of free radicals. This study assumed that ulinastatin would exert these effects on brain tissues that had been poisoned with paraquat. ...

Paraquat (1,1'-dimethyl-4,4'-bipyridylium dichloride) is a widely used herbicide and is highly toxic to human and animals. The mechanisms of paraquat toxicity involve the generation of superoxide anion through the process of redox cycling. NADPH-cytochrome P450 oxidoreductase (POR) has been reported to be a major enzyme for one-electron reduction of paraquat that initiates the redox cycling. Re...

In this study, we report on a case of transdermal paraquat poisoning combined with Pemphigus Vulgaris (PV). The patient was a 68 year old male farmer. He was exposed to paraquat (50% concentration) in a closed environment for 3 h, when the skin and respiratory symptoms of paraquat poisoning occurred. He was admitted to the hospital and diagnosed with transdermal paraquat poisoning combined with...