background secondary hyperparathyroidism (shpt) is a prevalent disorder in patients with chronic kidney disease. it is proffered that there is a contradictory relation between serum level of vitamin c and parathyroid hormone (pth) in hemodialysis patients with secondary hyperparathyroidism. objectives the goal of this study was to assess the effects of the supplemental vitamin c on parathyroid ...

Human parathyroid glands from a patient with chronic renal failure were used to study in vitro biosynthesis of immunoreactive parathyroid hormone. Parathyroid glands were incubated in the presence of [(3)H]leucine, and classical subcellular fractions were prepared. peptides from acetic acid extractions of the fractions were separated on Sephadex G-75 Superfine. Eluates were assayed for immunore...

BACKGROUND Numerous studies have reported that age-induced increased parathyroid hormone plasma levels are associated with cognitive decline and dementia. Little is known about the correlation that may exist between neurological processing speed, cognition and bone density in cases of hyperparathyroidism. Thus, we decided to determine if parathyroid hormone levels correlate to processing speed ...

By means of a statistical method for detecting distant evolutionary relationships between proteins, we found a high probability that internal homologies exist in preproparathyroid hormone, the biological precursor of proparathyroid hormone and parathyroid hormone. The regions so defined were -27 to +22 of preproparathyroid hormone vs. +26 to +74 parathyroid hormone and -23 to +29 of preproparat...

INTRODUCTION AND OBJECTIVE The risk of developing hypocalcemia is the reason for prolonged hospitalisation after total thyroidectomy. The objective of this study was to validate parathyroid hormone measurement for predicting post-thyroidectomy hypocalcemia. MATERIAL AND METHODS Eighty-two patients who underwent total or completion thyroidectomy from February 2009 to March 2010 were enrolled i...

Parathyroid hormone and other bone resorptive agents function, at least in part, by inducing osteoblasts to secrete cytokines that stimulate both differentiation and resorptive activity of osteoclasts. We previously identified two potentially important cytokines by demonstrating that parathyroid hormone induces expression by osteoblasts of IL-6 and leukemia inhibitory factor without affecting l...

Urinary excretion of cyclic adenosine 3',5'-monophosphate (3',5'-AMP) was tested in normal subjects and patients with pseudohypoparathyroidism, idiopathic hypoparathyroidism, surgical hypoparathyroidism, and pseudopseudohypoparathyroidism under basal conditions and after a 15 min infusion of purified parathyroid hormone. Basal excretion of the nucleotide was less than normal in the patients wit...

BACKGROUND Direct aspiration from suspected pathological tissue and rapid parathyroid hormone analysis may offer a reliable, cost effective alternative to currently used "gold standard" tests. OBJECTIVES To validate the accuracy of intraoperative measurements of parathyroid hormone levels in parathyroid adenomas. METHODS A prospective study included 22 patients diagnosed with primary hyperp...

renal failure: standards and audit measures (third edition). London: UK Renal Association, 2002. 2. Walker KS, Seth J. Stability of parathyroid hormone in blood from renal patients on haemodialysis. Ann Clin Biochem 2000;37:800–1. 3. Omar H, Chamberlin A, Walker V, Wood PJ. Immulite 2000 parathyroid hormone assay: stability of parathyroid hormone in EDTA blood kept at room temperature for 48 ho...

The deficiency of vitamin D is public among hemodialysis (HD) patients and a key factor in the development secondary hyperparathyroidism (SHPT). Secondary currently accomplished by lowering circulating phosphate levels with parathyroid hormone (PTH), analogs, oral binders. current study aim was to assess efficacy cholecalciferol management concomitant deficiency/insufficiency. A total 53 were t...