OBJECTIVES/HYPOTHESIS Additional intraoperative guidance could reduce the risk of iatrogenic injury during parotid gland cancer surgery. We evaluated the intraoperative use of fluorescently labeled nerve binding peptide NP41 to aid facial nerve identification and preservation during parotidectomy in an orthotopic model of murine parotid gland cancer. We also quantified the accuracy of intraoper...

BACKGROUND A modified Blair's incision or standard facelift incision is recommended to remove tumors in the accessory parotid gland. These incisions frequently result in long and visible scars. Therefore, the authors have introduced an endoscopic approach via a small preauricular incision to achieve excision of benign tumors in the accessory parotid gland. METHODS The endoscopic surgical tech...

Cancer of the parotid gland is relatively rare, but carries poor prognosis owing to its prevailing distant metastases. In addition to the disease's basic epidemiology and pathology, we review some current discoveries of its tumorigenesis molecular mechanism. Based on published salivary gland cancer clinical trial data, non-surgical antitumor efficacies amongst a range of chemotherapy, radiation...

Purpose: This study was conducted to explore the differences in salivary microRNA (miRNA) profiles between patients withmalignant or benign parotid gland tumors as a potential preoperative diagnostic tool of tumors in the salivary glands. Experimental Design:Whole saliva samples from patients with malignant (n1⁄4 38) or benign (n1⁄4 29) parotid gland tumors were obtained from the Salivary Gland...

Purpose: This study was conducted to explore the differences in salivary microRNA (miRNA) profiles between patients withmalignant or benign parotid gland tumors as a potential preoperative diagnostic tool of tumors in the salivary glands. Experimental Design:Whole saliva samples from patients with malignant (n1⁄4 38) or benign (n1⁄4 29) parotid gland tumors were obtained from the Salivary Gland...

Introduction: Salivary gland tumors are relatively rare and constitute 3-4% of all head and neck neoplasms. The majority (70%) of salivary gland tumors arise in the parotid gland. Recommended treatment for a parotid mass is surgical excision with a surrounding cuff of normal tissue to prevent recurrence. Materials and Methods: This is a retrospective study of 300 patients who were operated b...

The anti-apoptotic protein Mcl-1 is highly expressed in various types of malignant tumors. Overexpression is reported to correlate with poor prognosis and disease progression. We report the expression levels of Mcl-1 in tumor samples of the parotid gland. A retrospective study containing 108 patients was performed. A tissue microarray of six malignancies of the parotid gland and pleomorphic ade...

BACKGROUND/AIM Human papillomavirus (HPV) is implicated in head and neck squamous cell carcinomas. However, the causal role of HPV in carcinomas of the parotid gland remains uncertain and less documented. This study aimed to determine the potential implication of HPV in the development of benign and malignant lesions of the parotid gland. MATERIALS AND METHODS Paraffin-embedded biopsies were ...

introduction: salivary gland tumors are relatively rare and constitute 3-4% of all head and neck neoplasms. the majority (70%) of salivary gland tumors arise in the parotid gland. recommended treatment for a parotid mass is surgical excision with a surrounding cuff of normal tissue to prevent recurrence. materials and methods: this is a retrospective study of 300 patients who were operated by a...

introduction: mucoepidermoid carcinoma represents one of the most common malignant salivary gland tumors.however, the sclerosing morphologic variant is extremely rare with only 23 reported cases in the english-language literature since it was discovered in 1987. case report: herein, we describe another case that was diagnosed in a 25-year-old woman presenting with a posterior auricular mass, as...