Diabetes mellitus is accompanied with disturbances in learning, memory, and cognitive skills in the human society and experimental animals. Therefore, this research study was conducted to evaluate time-dependent changes in passive avoidance and Y-maze performance in male diabetic rats. For this purpose, male Wistar rats were randomly divided into control and diabetic groups. For induction of di...

Alzheimer’s disease (AD) is a chronic neurodegenerative disease causing progressive impairment of memory and cognitive function. Streptozotocin (STZ) injection into the brain is known to cause cognitive impairment in rats and is similar to sporadic AD in humans. Several lines of evidence have indicated that an inflammatory process contributes to the pathology of AD. On the basis of the results ...

Alzheimer’s disease (AD) is a chronic neurodegenerative disease causing progressive impairment of memory and cognitive function. Streptozotocin (STZ) injection into the brain is known to cause cognitive impairment in rats and is similar to sporadic AD in humans. Several lines of evidence have indicated that an inflammatory process contributes to the pathology of AD. On the basis of the results ...

introduction: cholinergic systems are involved in learning and memory. scopolamine, a muscarinic acetylcholine receptor antagonist, is used as a standard/ reference drug for inducing cognitive deficits in healthy humans and animals. the purpose of this study was to evaluate the effects of scopolamine on avoidance memory and number of neurons in rat’s hippocampus. . methods: thirty five male alb...

background: it has been reported that epilepsy is a disorder of the central nervous system that causes memory impairment. this study examines the role of the aqueous extract of boswellia on the learning disability of the pentylenetetrazol (ptz)‑induced kindled rats. methods: in this experimental study, 64 male rats were used. kindling seizures were induced by three injections of 25 mg/kg of ptz...

The effect of blockade of 5-HT1A receptors was investigated on (1). retention in a mildly aversive passive-avoidance task, and (2). spontaneous single-unit activity of central nucleus of the amygdala (CeA) neurons, a brain site implicated in modulation of retention. Systemic administration of the selective 5-HT1A antagonist NAN-190 immediately after training markedly-and dose-dependently-facili...

Background: Dipentyl phthalate (DPeP) is a plasticizer compound commonly used in polyvinylchloride plastic to increase their softness and flexibility. They are not bound covalently to the plastic polymers and can therefore leach out into the environment, and have been shown to adversely affect the health of humans and animals. Methods: We investigated the effect of DPeP on the various cognitive...