Inspection of the paleontologic history of many phyla shows that when certain members of a series of polyisomeres have been subjected to in-. creasing stresses through long periods of geologic time, they have often become enlarged, strengthened or fused with their neighbors and have thereby passed into a state of anisomerism. Thus taxonomy, paleontology, comparative anatomy, genetics, experimen...

Antispleen antibody was produced in burros by immunization with C57BL/6 spleen lymphocytes. The effect of passive administration of this antiserum in inhibiting antibody production to antigenic determinants common to both C57BL/6 lymphocytes and EL4 tumor cells was studied. Simultaneous immunization with EL4 cells and antispleen antibody resulted in specific alteration of anti-EL4 activity so t...

The binding of complement factor H (fH) to meningococci was recently found to be specific for human fH. Therefore, passive protective antibody activity measured in animal models of meningococcal bacteremia may overestimate protection in humans, since in the absence of bound fH, complement activation is not downregulated. We developed an ex vivo model of meningococcal bacteremia using nonimmune ...

Passive immunization is a method to achieve immediate protection against infectious agents by administering pathogen-specific antibodies. It has proven to be lifesaving for many acute infections, and it is now also used for cancer treatment. Passive immunization therapies, however, are extremely expensive because they require large amounts of specific antibodies that are produced predominantly ...