In this study, novel hydrophilic multiblock copolymers composed of semi-crystalline poly(ε-caprolactone) [PCL] blocks and amorphous blocks consisting of poly(D,Llactide) (PDLA) and poly(ethylene glycol) (PEG) [PDLA-PEG] were synthesized. The block ratio of these [PDLA-PEG]-b-[PCL] multiblock copolymers was varied and the degradation of implants prepared of these polymers by hot melt extrusion (...

Multidrug resistance (MDR) in tumor cells is a significant obstacle to the success of chemotherapy in many cancers. The purpose of this research is to test the possibility of docetaxel-loaded poly (ε-caprolactone)/Pluronic F68 (PCL/Pluronic F68) nanoparticles to overcome MDR in docetaxel-resistance human breast cancer cell line. Docetaxel-loaded nanoparticles were prepared by modified solvent d...

Polyethylene Glycol Diacrylate (PEGDA) tissue scaffolds having a thickness higher than 1 mm and without the presence of nutrient conduit networks were shown to have limited applications in tissue engineering due to the inability of cells to adhere and migrate within the scaffold. The PEGDA scaffold has been coated with polycaprolactone (PCL) electrospun nanofiber (ENF) membrane on both sides to...

OBJECTIVES Because posterior cruciate ligament (PCL) resection makes flexion gaps wider in total knee replacement (TKR), preserving or sacrificing a PCL affects the gap equivalence; however, there are no criteria for the PCL resection that consider gap situations of each knee. This study aims to investigate gap characteristics of knees and to consider the criteria for PCL resection. METHODS T...

Musculoskeletal tissue engineering aims at repairing and regenerating damaged tissues using biological tissue substitutes. One approach to achieve this aim is to develop osteoconductive scaffolds that facilitate the formation of functional bone tissue. We have fabricated nanoclay-enriched electrospun poly(ɛ-caprolactone) (PCL) scaffolds for osteogenic differentiation of human mesenchymal stem c...

Polycystin-L (PCL), the third member of the polycystin family of proteins, functions as a Ca2+-modulated nonselective cation channel when expressed in Xenopus oocytes. Polycystin-1 and -2 are mutated in autosomal-dominant polycystic kidney disease (ADPKD), but the role of PCL in disease has not been determined. In this study, an anti-peptide polyclonal antiserum was generated against the carbox...

We report an investigation of the influence of block copolymer architectures on formation of nanophases in epoxy thermosets via reactioninduced microphase separation approach. Toward this end, three binary block copolymers composed of polystyrene (PS) and poly(ε-caprolactone) (PCL) were synthesized via the combination of ring-opening polymerization (ROP) and atomic transfer radical polymerizati...

Compositionally graded bulk materials of organic polymer blends were prepared by using nonequilibrium self-organization processes with a uniaxial thermal gradient (Bridgman method). The Bridgman method was firstly applied to prepare two kinds of polymeric compositionally graded materials: a polymer/low molecular weight additive system (poly(e-caprolactone) (PCL)/ 4,49-thiodiphenol (TDP)) and a ...

The effects of replacing PCL with acrylic acid grafted PCL (PCL-g-AA) on the structure and properties of a PCL/chitosan composite were investigated. The properties of both PCL-g-AA/chitosan and PCL/chitosan were examined and compared using FTIR, H and C nuclear magnetic resonance (NMR), differential scanning calorimetry (DSC), and a biodegradation test. With PCL-g-AA in the composite, compatibi...

Plasma cell leukemia (PCL) is a rare disease that represents approximately 4% of plasma cell malignant disorders. PCL consists of two variants: primary PCL presents in patients with no previous history of multiple myeloma, while secondary PCL consists of a leukemic transformation in a previously recognized multiple myeloma. Primary PCL is an extremely resistant, rapidly progressive, fatal disea...