Periodontal repair is a complex process in which regeneration of alveolar bone is a vital component. The aim of this study was to develop a biodegradable scaffold with good biocompatibility and osteoinductive ability. Two types of composite fibrous scaffolds were produced by electrospinning, ie, type I collagen/poly(ε-caprolactone) (COL/PCL) and type I collagen/poly(ε-caprolactone)/nanoscale hy...

One of the determinant factors for successful bioengineering is to achieve appropriate nano-topography and three-dimensional substrate. In this research, polycaprolactone (PCL) nano-fibrous mat with different roughness modified with O2 plasma was fabricated via electrospinning. The purpose of this study was to evaluate the effect of plasma modification along with surface nano-topography of mats...

The composite group investigates endlessly the features of natural fiber/thermoplastic matrix materials to improve recyclability, use renewable sources, and reduce material costs. In this context, development biodegradable polymers for composites is considered one important strategies reducing environmental challenges. Here, axially oriented fibers incorporated in conforming matrices make up fi...

A new simple and reliable method for rapid and selective extraction and determination of trace levels of Zn(II) ion is developed. Zn(II) ions are adsorbed quantitatively during passage of aqueous samples through PET-AA/AAm nano fiber modified. Almost all matrix elements were found to pass through the nano fiber to drain. Modified Poly (ethylene terephthalate)-grafted-Acrylic acid/Acryl amide Na...

A new simple and reliable method for rapid and selective extraction and determination of trace levels of Zn(II) ion is developed. Zn(II) ions are adsorbed quantitatively during passage of aqueous samples through PET-AA/AAm nano fiber modified. Almost all matrix elements were found to pass through the nano fiber to drain. Modified Poly (ethylene terephthalate)-grafted-Acrylic acid/Acryl amide Na...

The blood-brain barrier is a substantial obstacle for delivering anticancer agents to brain tumors, and new strategies for bypassing it are sorely needed for brain tumor therapy. Intranasal delivery provides a practical, noninvasive method for delivering therapeutic agents to the brain. Intranasal application of nano-sized micelles that have been modified with Tat peptide facilitates brain deli...

The surface morphology of micro- and nano- scale fiber determines its application to a great extent. At present, variety secondary microfibers nanofibers, such as porous, wrinkle, groove so on, have been prepared. Among them, grooved fibers are attracting more attention because their unique properties. In this paper, we review the literature on due void-based elongation, wrinkle-based collapsed...

The present study records on in vivo evaluation of  ve types of electrospun nano brous matrices, viz., collagen, gelatin, polycaprolactone (PCL), collagen-PCL (1:1) and Gelatin-PCL (1:1), prepared with a novel benign solvent in a rat model on wound healing. Granulation tissue formation was observed in the subcutaneous implanted tissue. There was no indication of gross rejection of the implant...

Electrospun polycaprolacyone/polymethacrylic acid graft copolymer nanofibers (PCL/MAA) containing silver nanoparticles (AgNPs) were synthesized for effective wound disinfection. Surface morphology, AgNPs content, water uptake of electrospun PCL/MAA graft copolymer nanofibers without and with AgNPs, and levels of AgNPs leaching from the nanofibers in water as well as antimicrobial efficacy were ...

ID4, a helix loop helix transcriptional regulator has emerged as a tumor suppressor in prostate cancer. Epigenetic silencing of ID4 promotes prostate cancer whereas ectopic expression in prostate cancer cell lines blocks cancer phenotype. To directly investigate the anti-tumor property, full length human recombinant ID4 encapsulated in biodegradable Polycaprolactone/Maltodextrin (PCL-MD) nano-c...