Novel synthetic methodologies allow increasingly efficient access to known organic materials, as well as the preparation of otherwise inaccessible species. Pd-catalyzed coupling of aromatic dihalides to ortho-diaminoarenes furnishes embedded stable N,N'-dihydropyrazines expediently and in often excellent yields. The embedded N,N'-dihydropyrazines can then be oxidized by MnO2 to give substituted...

Age at onset of renal replacement therapy (RRT) is increasing in all countries. Two substitution methods of renal function remain available: hemodialysis (HD) and peritoneal dialysis (PD). It was a retrospective study carried out on January 2015 and it included patients older than 65 years, monitored for HD and PD. We studied their epidemiological and clinical profile, their evolution, and the ...

The unique minerals of the Au-Pd-Hg system in gold grains from heavy concentrates Itchayvayam placers and watercourses draining ore samples Barany outcrop at mafic–ultramafic complex (Kamchatka, Russia) were investigated. Gold contain substitution structures formed by Pd,Hg-rich low-fineness (Au0.59–0.52Pd0.24–0.25Hg0.17–0.23, 580‰–660‰) Pd,Hg-poor high-fineness (Au0.94–0.90Pd0.02–0.04Hg0.03, 9...

Although peritoneal dialysis (PD) has been advocated as a suitable substitution therapy in patients with failure of hemodialysis (HD) blood access, documentation of the performance of PD in such patients is limited. Here, we present an elderly patient with total failure of HD blood access who has had a remarkably successful course on PD. A 78-year-old man with several comorbidities started cont...

Mutations in the angiogenic factor, angiogenin (ANG), have been identified in patients with both familial and sporadic amyotrophic lateral sclerosis (ALS) and are thought to have a neuroprotective function. Parkinsonism has been noted in kindreds with ANG mutations and variants in the ANG gene have been found to associate with PD in two Caucasian populations. We therefore hypothesized that muta...

Electronic differentiations in Pd-catalyzed allylic substitutions are assessed computationally from transition structure models with electronically modified phospha-benzene-pyridine ligands. Although donor/acceptor substitutions at P and N ligand sites were expected to increase the site selectivity, i.e. the preference for "trans to P" attack at the allylic intermediate, acceptor/acceptor subst...

Some of the most efficient homogeneous catalysts for the lowtemperature, selective oxidation of methane to functionalized products employ a mechanism involving C H activation with an electrophilic substitution mechanism. Several such systems have been reported based on the cations Hg, Pd, and Pt. These catalyst systems typically operate by two general steps that involve: A) C H activation by co...

Reaction of Na-,PdCl4 with N-ferrocenylmethylidene-2,4,6-trimethylaniline yields the di­ meric, chloro-bridged Pd(II) complex [Pd{(C5H 5)FeC5H 3C(H )=N -2 ,4,6-(CH3)3C6H2}Cl]2. The title complex (1 ) is obtained by substitution of the chloro-bridges with acetate. 1 crystallizes in the orthorhombic space group Pbca with the lattice parameters a = 1346.4(4), b = 2876.6(2), c = 2472.8(5) pm and Z ...

In contrast to almost all of the known examples of Heck arylation of unsaturated alcohols, which yield predominately beta-arylated products, arylation under the Pd-DPPP catalysis in ionic liquid leads preferentially to aryl substitution at the alpha carbon, providing an easy pathway to this valuable class of olefins.