Currently, the sole strategy for managing food hypersensitivity involves strict avoidance of the trigger. Several alternate strategies for the treatment of food allergies are currently under study. Also being explored is the process of eliminating allergenic proteins from crop plants. Legumes are a rich source of protein and are an essential component of the human diet. Unfortunately, legumes, ...

BACKGROUND Natural allergen sources can supply large quantities of authentic allergen mixtures for use as immunotherapeutics. However, such extracts are complex, difficult to define, vary from batch to batch, which may lead to unpredictable efficacy and/or unacceptable levels of side effects. The use of recombinant expression systems for allergen production can alleviate some of these issues. S...

Allergies involve a state of immediate hypersensitivity to antigens, including food proteins. The mechanism underlying the initiation and development of allergic responses involves IL-4 that directly induces the differentiation of committed effector Th2 lymphocytes. Although it is clear that Th2 responses play a pivotal role in the development of allergic responses, it remains unclear which mec...

Food anaphylaxis is now the leading known cause of anaphylactic reactions treated in emergency departments in the United States. It is estimated that there are 30 000 anaphylactic reactions to foods treated in emergency departments and 150 to 200 deaths each year. Peanuts, tree nuts, fish, and shellfish account for most severe food anaphylactic reactions. Although clearly a form of immunoglobul...

BACKGROUND Food allergies (FAs) affect 2-4% of school-aged children in developed countries and strongly impact their quality of life. The prevalence of FA in Chile remains unknown. METHODS Cross-sectional survey study of 488 parents of school-aged children from Santiago who were asked to complete a FA screening questionnaire. Parents who reported symptoms suggestive of FA were contacted to an...

BACKGROUND To halt the increase in peanut allergy, we must determine how children become sensitized to peanut. High household peanut consumption used as an indirect marker of environmental peanut exposure is associated with the development of peanut allergy. OBJECTIVE We sought to validate a method to quantify environmental peanut exposure, to determine how peanut is transferred into the envi...

the increasing cost of peanut production is a major concern in iran. therefore, developing the mechanization of peanut production is a necessity. in this regard, a three-phase delphi study was conducted to identify the promoting and deterring factors affecting peanut cultivation mechanization in guilan province, the main peanut-producing region in iran. after preliminary studies, 26 experts wer...

Drought is a serious environmental stress limiting growth and productivity in peanut and other crops. Nutrient uptake of peanut is reduced under drought condition, which reduces yield. The objectives of this study were to investigate nutrient uptake of peanut genotypes in response to drought and to estimate the relationship between nutrient uptake and peanut yield under different water regi...

OBJECTIVES To determine whether there are any differences between children who remain mildly or moderately allergic to peanut and children with similar histories but a negative reaction on challenge with peanut. DESIGN Case-controls matched for age and sex. SETTING Children's day wards in two teaching hospitals. INTERVENTION Open food challenge with peanut. SUBJECTS 15 children with res...

PURPOSE The purpose of this study was to establish the diagnostic decision point (DDP) of peanut specific IgE (sIgE) for predicting the outcome of oral food challenge (OFC). We also evaluated the usefulness of sIgE to peanut components (Ara h 1, 2, 3, 8, and 9) in diagnosing peanut allergy. METHODS Korean children aged over 12 months with a suspected peanut allergy were enrolled. Diagnosis of...