نتایج جستجو برای: pemetrexed

تعداد نتایج: 3190  

Journal: :Anticancer research 2010
D Schallier L Decoster C Fontaine J De Grève

BACKGROUND Pemetrexed-induced eyelid edema is a rare side-effect of pemetrexed treatment. PATIENTS AND METHODS Retrospective analysis of the incidence and severity of eyelid edema was conducted in patients treated with pemetrexed in a single institution. RESULTS Eighty-six patients received pemetrexed-containing chemotherapy either as a single agent (45 patients) or in combination with cis-...

Journal: :Annali italiani di chirurgia 2014
Serena Valerio Umberto Marcello Bracale Anna Maria Giribono Emanuela Viviani Federica Caioni Luca del Guercio

Pemetrexed and Carboplatin are two well-known chemioterapic agents used for the treatment of many tumors, especially for lung cancer and mesothelioma. Peripheral ischemic events related to Pemetrexed and Carboplatin are rarely reported. We herein report a case of lower limb acute ischemia related to combined treatment of Pemetrexed and Carboplatin. A 68-year-old woman was given the chemiotherap...

Journal: :International journal of oncology 2016
Ralph Zinner Carla Visseren-Grul David R Spigel Coleman Obasaju

Because poor performance status (PS) is an independent prognostic factor in non-small cell lung cancer (NSCLC), PS scores are widely used by oncologists to make treatment decisions. Advanced NSCLC patients with an Eastern Cooperative Oncology Group PS of 2 have poor prognoses and are frequently excluded from clinical trials. This article reviews the efficacy and safety of pemetrexed in this pat...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2004
Elisa Giovannetti Valentina Mey Romano Danesi Irene Mosca Mario Del Tacca

PURPOSE Gemcitabine is an inhibitor of ribonucleotide reductase (RR) and DNA synthesis and is an effective agent in the treatment of pancreas cancer. The present study investigates whether the multitargeted antifolate pemetrexed would be synergistic with gemcitabine against MIA PaCa-2, PANC-1, and Capan-1 pancreatic cancer cell lines. EXPERIMENTAL DESIGN Cells were treated with gemcitabine an...

2017
Toshiyuki Satoh Takeo Tatsuta Shigeki Sugawara Akiyoshi Hara Masahiro Hosono

Malignant mesothelioma is an aggressive cancer with limited therapeutic options. Sialic acid-binding lectin isolated from Rana catesbeiana oocytes (cSBL) is a multifunctional protein with anti-cancer activity. The effects of pemetrexed, cisplatin, and cSBL were evaluated in mesothelioma and normal mesothelial cell lines. We evaluated cytotoxicity, apoptosis, caspase-3 cleavage and activation, c...

Journal: :Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 2012
Klazien Matter-Walstra Markus Joerger Ursula Kühnel Thomas Szucs Bernhard Pestalozzi Matthias Schwenkglenks

OBJECTIVES A recent randomized study showed switch maintenance with pemetrexed after nonpemetrexed-containing first-line chemotherapy in patients with advanced nonsmall-cell lung cancer to prolong overall survival by 2.8 months. We examined the cost-effectiveness of pemetrexed in this indication, from the perspective of the Swiss health care system, and assessed the influence of the costs of be...

2011
Binod Dhakal Veerpal Singh Anuj Shrestha Arjun Rao Nicholas Choong

Pemetrexed is an antifolate chemotherapy agent that is active in malignant mesothelioma and non-small cell lung cancer (NSCLC). Pneumonitis is a rare side effect of Pemetrexed. We report the case of 72-year-old female with metastatic poorly differentiated lung adenocarcinoma. She was placed on maintenance pemetrexed and developed gradual progressive dyspnea after first cycle of maintenance of p...

Journal: :Asian Pacific journal of cancer prevention : APJCP 2014
Jin Liu Xin-En Huang Ji-Feng Feng

OBJECTIVE To further observe the efficacy and safety of pemetrexed, combined with Irinotecan or oxaliplatin or cisplatin in treating patients with advanced gastric cancer as second-line or third-line chemotherapy. METHODS From September 2013 to February 2014 we recruited 50 patients with advanced gastric cancer, with stage IV disease or postoperative recurrence, or unresectable. Then treated ...

Journal: :Oncology 2004
Axel R Hanauske Christian Dittrich Jorge Otero

Pemetrexed (Alimta) is an antifolate that is effective in the inhibition of multiple enzyme targets including thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyl transferase. The compound has been evaluated in several phase I trials, both as single agent and in combination with other cytotoxic agents. The initial schedule selected for further investigation in ph...

2017
Yassir Sbitti Hafsa Chahdi Khaoula Slimani Adil Debbagh Anouar Mokhlis Abderrahmane Albouzidi Fahd Bennani Hassan Errihani Mohamed Ichou

BACKGROUND Pemetrexed maintenance therapy holds tremendous potential in improving the survival of patients with advanced pulmonary adenocarcinoma. Major side effects include myelosuppression and cutaneous reactions. However, little data are available on pemetrexed nephrotoxicity. Our case describes clinically relevant renal events leading to treatment discontinuation in routine practice. CASE...

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