The size of a nanomedicine strongly correlates with its biodistribution, tissue penetration, and cell uptake. However, there is limited understanding how the size of nanomedicine impacts the overall antitumor efficacy. We designed and synthesized camptothecin-silica nanoconjugates (Cpt-NCs) with monodisperse particle sizes of 50 and 200 nm, two representative sizes commonly used in drug deliver...

Abstract The liquefaction event that occurred in Petobo Village, Palu City, Central Sulawesi, was caused by the earthquake on September 28 th , 2018 with a magnitude of 7.4 and depth 10 km. This study aims to determine characteristics soil also whether area still has potential for based Test Swedish Weight Sounding (SWS) Cone Penetration (CPT) . test is carried out at location limit cessation l...

The electric cone penetration test (CPT) has been in use for over 40 years and is growing in popularity in North America. This paper provides some recent updates on the interpretation of some key geotechnical parameters in an effort to develop a more unified approach. Extensive use is made of the normalized soil behaviour type (SBTn) chart based on normalized cone resistance (Qt) and normalized...

Abstract Each pile in an offshore wind farm may be designed solely on the results of a single cone penetration test (CPT) positioned at its center or based sample statistics calculated from multiple investigated locations same geotechnical unit. This study investigates quantitatively effects spatial variability soil efficacy two approaches to achieve reliable design. Random field theory is used...

Liquefaction of soil is one of the major causes for the significant damages to the buildings, lifeline systems and harbor facilities caused by the earthquakes. At present artificial intelligence techniques such as artificial neural network (ANN) and support vector machine (SVM) based models are found to be more efficient compared to statistical methods. The present study discusses about the eva...

Artificial neural networks (ANNs) are often used recently by researchers to solve complex and nonlinear problems. Standard penetration test (SPT) cone (CPT) field tests that obtain soil parameters. There have been many previous studies examined the value obtained through SPT with CPT test, but research carried out still uses equations linear. This will conduct an estimated of on cohesive using ...

Cone penetration testing (CPT) is a widely used geotechnical engineering in-situ test for mapping soil profiles and assessing properties. In CPT, cone on the end of series rods pushed into ground at constant rate resistance to tip measured (qm). The qm values are utilized characterize profile. Unfortunately, blurred and/or averaged which can result in distortion profile characterization inabili...