This study evaluated the efficacy of penicillin in improving culture yield M. Tuberculosis cases pulmonary tuberculosis. A retrospective was conducted Department Pathology, MMDC, Multan. total 350 suspected tuberculosis patients were selected for study. An early morning sputum specimen collected. NAOH citrate and N-acetyl-L-cysteine used digesting, decontaminating, homogenizing sputum. The samp...

Penicillin-resistant strains of Streptococcus pneumoniae possess altered forms of penicillin-binding proteins (PBPs) with decreased affinity for penicillin. The PBP2B genes of these strains have a mosaic structure, consisting of regions that are very similar to those in penicillin-sensitive strains, alternating with regions that are highly diverged. Penicillin-resistant strains of viridans grou...

BACKGROUND Up to 10% of the population reports an allergy to penicillin, yet more than 80% of these individuals lack penicillin-specific IgE antibodies. A negative result on a penicillin skin test is highly accurate in identifying who can safely receive the antibiotic at the time of testing. However, its negative predictive value for future courses is unknown because it is uncertain whether pat...

BACKGROUND People with a history of rheumatic fever (RF) are at high risk of recurrent attacks and of developing rheumatic heart disease following a streptococcal throat infection. Giving penicillin to these people can prevent recurrent attacks of RF and subsequent rheumatic heart disease. However, there is no agreement on the most effective method of giving penicillin. OBJECTIVES To assess t...

Penicillin, clindamycin, and intravenous immune globulin (Venoglobulin-S; IVIG) alone and in combination were studied in a murine model of group A streptococcal necrotizing fasciitis. As assessed by bacterial clearance, treatment with IVIG was not significantly different from no treatment. All treatment regimens that contained penicillin or clindamycin were more effective (P<.05) than no treatm...

In this study, after identification of genes involved in biosynthesis of penicillin, we evaluated the expression of pcbAB and pcbC genes in P.  Chrysogenum.  A quantitative PCR (qPCR) approach was used to determine how these genes were expressed in different time courses. In addition, the produced penicillin content was measured using HPLC. qPCR analysis of mRNAs extracted from P. chrysogenum i...

Validation process is a program for ensuring products with proven acceptable and predetermined specification. The LAL test used for detection of endotoxin in the sterile parenteral products is one of the tests that require validation. During this study, validation of 12 parenteral antibiotics including penicillin and cephalosporin have been done using gel clot method and obtained results which ...