Simvastatin hydroxy acid (SVA), the pharmacologically active form of simvastatin (SV), is a potent inhibitor of 3-hydroxy-3-methylglutaryl (HMG)-coenzyme A reductase and is formed on hydrolysis of the orally administered SV. In this article, we report the structural characterization of two new dihydroxy glutathione adducts and a trihydroxy derivative of SVA, all found in rat bile. Metabolite I ...

Elevated serum cholesterol, a major cause of vascular disease, has been strongly correlated with eating greater than normal amounts of cholesterol and saturated fatty acids. The role at omega-3 polyunsaturated fatty acids (PUFA), especially eicosa pentanoic acid (EPA) and decosahexaconic (DHA), has been associated with the prevention of degenerative disease. Breast milk and eggs fulfill the hum...

In the ®rst of the title compounds, (2S)-2-(1-oxo-1H-2,3dihydroisoindol-2-yl)pentanoic acid, C13H15NO3, prepared from l-norvaline, a hydrogen-bonded network is formed in the solid state through OÐH O C, CÐH O C and CÐ H arene intermolecular interactions, with shortest O O, C O and C centroid distances of 2.582 (13), 3.231 (11) and 3.466 (3) AÊ , respectively. In the l-valine derivative, (2S)-3m...

essential oils are considered as very complex natural mixtures containing numerous components at quite various concentrations. lythrum salicaria has not been previously subjected to examination of its volatile oil. the present study was carried out to evaluate the essential oil composition of the flowering aerial parts of the plant by using conventionally hydro-distillation (hd) and microwave a...

The biological and organoleptic properties of Bulgarian yogurt are largely determined by the metabolic activity selected strains Lactobacillus delbrueckii ssp. bulgaricus. HS-SPME-GC-MS technique was used to analyze volatile compounds produced following strains: bulgaricus MG1, MG2, MG3 MG4, MG5 MG6, MG7 MG8. A study optimize conditions SPME performed. optimum extraction aromatic components obt...

We have studied four organic acids of similar structure to further understand the basis of their developmental toxicity. Valproic acid (2-propyl pentanoic acid), ethylhexanoic acid, and octanoic acid are isomeric C8 organic acids but their teratologic potency varied widely. Valproic acid induced a moderate to severe teratologic outcome after a single oral administration of 6.25 mmoles/kg on day...

This study reports a new approach for the synthesis of 5-[2-(2-carboxyethyl)-3-[6-(4-methoxyphenyl)-(5E)-hexen-1-yloxy]phenoxy]pentanoic acid V (ONO-LB-457), previously described by Konno and col. which is considered highly potent orally active LTB4 receptor antagonist. compound acts as an inhibitor aggregation chemotaxis, in addition to LTB4-induced human neutrophil degranulation. In this work...

Chemical bond cleavage and reconstruction are common processes in traditional rearrangement reactions. In contrast, the process that involves bond cleavage, fragment modification and then reconstruction of the modified fragment provides an efficient way to build structurally diversified molecules. Here, we report a palladium(II)/chiral phosphoric acid catalysed three-component reaction of aryld...

Methyl valerate (VAME), also known as methyl pentanoate, is the methyl ester of the pentanoic acid (valeric acid). VAME is usually used as fragrance in the production of beauty care, soap and laundry detergents. High purity of VAME can also be used as plasticizer. This study presents the design details of the process for the manufacture of VAME. Reactive distillation column (RDC) is used in the...

The requirement for developing an instrumental method analysis of volatile compounds responsible the aroma that supports work sensory panel test virgin olive oils is a matter great importance. In this paper, five laboratories participated in collaborative study within EU H2020 OLEUM project to develop peer interlaboratory harmonized SPME-GC-MS determination oil positive attributes (e.g. fruity)...