BACKGROUND In the last 3 decades, and from a therapeutic point of view, the classical concept of ischemic penumbra based on hemodynamic and electrophysiological parameters has loosened up the rigidity of therapeutic windows in acute stroke management. Thirty years later, the ischemic penumbra is an evolved concept that presents more applications. Thus, the ischemic penumbra is a diagnostic targ...

Vector magnetic fields of moving magnetic features (MMFs) are well observed with the Solar Optical Telescope (SOT) aboard the Hinode satellite. We focus on the evolution of three MMFs with the SOT in this study. We found that an MMF having relatively vertical fields with polarity same as the sunspot is detached from the penumbra around the granules appeared in the outer penumbra. This suggests ...

BACKGROUND AND PURPOSE In vivo panoramic imaging of reduced nicotinamide adenine dinucleotide (NADH), intracellular brain pH (pHi), and cortical blood flow was used to characterize the ischemic penumbra during focal ischemia. During global ischemia, hypoxia, and status epilepticus, the development of cortical acidic foci has been observed. The hypothesis tested was that during focal ischemia, a...

BACKGROUND AND PURPOSE Stroke-prone spontaneously hypertensive rats (SHRSP) are a highly pertinent stroke model with increased sensitivity to focal ischemia compared with the normotensive reference strain (Wistar-Kyoto rats; WKY). Study aims were to investigate temporal changes in the ischemic penumbra in SHRSP compared with WKY. METHODS Permanent middle cerebral artery occlusion was induced ...

We have measured velocity maps of a round sunspot near the center of the solar disk. We derive the small-scale velocity field of the penumbra in the deep photosphere. Superimposed on a radial outflow, we find up– and downflows, which are associated with bright and dark features: The flow in the dark component of the penumbra has a larger inclination angle with respect to the surface normal than...

Mueller, Frank. M.S., Purdue University, May, 2004. Penumbra: Enhancing Eclipse for Introductory Programming. Major Professor: Antony L. Hosking. In recent years, Java has become the most popular programming language for introductory programming courses; however, there has been a lack of a good Java development environment for novice computer science students. We decided to adapt Eclipse for te...

The management of acute “brain attack” is in evolution. A proliferation of new treatment approaches directed at lysing thrombus, normalizing cerebral perfusion, and reversing or minimizing neuronal ischemic damage are recently approved or currently under investigation. Preservation of “tissue at risk” within the ischemic penumbra is the goal of many of these newer therapies. The ischemic penumb...

AIMS The aim of this study was to assess the association between the proportions of penumbra-visualized by late gadolinium enhanced cardiovascular magnetic resonance imaging (LGE-CMR)-after acute myocardial infarction (AMI) and the prevalence of ventricular tachycardia (VT). METHODS One-hundred and sixty-two AMI patients, successfully, treated by primary percutaneous coronary intervention (PC...

BACKGROUND AND PURPOSE Penumbral biomarkers promise to individualize treatment windows in acute ischemic stroke. We used a novel magnetic resonance imaging approach that measures oxygen metabolic index (OMI), a parameter closely related to positron emission tomography-derived cerebral metabolic rate of oxygen utilization (CMRO2), to derive a pair of ischemic thresholds: (1) an irreversible-inju...