A Peptic ulcer is a mucosal lesion of the stomach or duodenum in which the acid and pepsin play major pathogenic roles. The major forms of peptic ulcer are gastric ulcer and duodenal ulcer, both of which are chronic diseases often caused by Helicobacter pylori. The term peptic ulcer also encompasses gastric ulcers and duodenal ulcers associated with stress or the ingestion of drugs, most common...

PROLOGUE Peptic ulcer, an excavation in the mucosal lining penetrating below the muscularis mucosa of the stomach or duodenum (See Figure 1), is a common disorder. The incidence varies with the age, gender, and geographical location with duodenal ulcers occurring in approximately four to ten percent of the United States (U.S.) population and gastric ulcers occurring in less than one percent. Bo...

Refractory peptic ulceration refers to ulcers which are slow to heal despite active treatment for at least three months. Oxygen-derived free radicals are cytotoxic and promote tissue injury. Twelve consecutive patients with refractory peptic ulceration (eight with duodenal ulcers and four with solitary pre-pyloric gastric ulcers) were treated using the radical scavengers allopurinol or dimethyl...

Healing of peptic ulcers can be achieved by using a variety of anti-ulcer medications. The most commonly used agents include the histamine-2 receptor antagonists (H2RAs) and the proton pump inhibitors. They are also efficacious in preventing ulcer recurrence providing maintenance treatment is given. The ideal treatment for peptic ulcers today is aiming at eradication of Helicobacter pylori infe...

Peptic ulcer disease represents a serious medical problem. Approximately 500,000 new cases are reported each year, with 5 million people affected in the United States alone. Interestingly, those at the highest risk of contracting peptic ulcer disease are those generations born around the middle of the 20th century. Ulcer disease has become a disease predominantly affecting the older population,...

Big differences in the prevalence of peptic ulcer are known to exist in different parts of India. This paper reports a high incidence in Assam and records certain differences with peptic ulcers found in south India.