نتایج جستجو برای: percutaneous absorption

تعداد نتایج: 187163  

Journal: :Journal of Investigative Dermatology 1968

Journal: :Archives of Disease in Childhood - Fetal and Neonatal Edition 1994

Journal: :Chemical and Pharmaceutical Bulletin 1987

Journal: :Journal of Investigative Dermatology 1984

Journal: :Clinical Pharmacokinetics 1993

Journal: :Brazilian Archives of Biology and Technology 2007

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2003
Jean-Paul Payan Isabelle Boudry Dominique Beydon Jean-Paul Fabry Marie-Christine Grandclaude Elisabeth Ferrari Jean-Claude André

Neat N-methyl-2-pyrrolidone (NMP) rapidly penetrated into the skin of male Sprague-Dawley rats after in vivo and in vitro topical application. At the two topical doses tested in vivo, no steady state was observed. The maximal absorption fluxes were 10 and 20 mg/cm(2)/h for 20 microl/cm(2) and 40 microl/cm(2), respectively. Similar results were observed after in vitro topical application of neat...

2005
Hirokazu OKAMOTO Takashi SAKAI Kazumi DANJO

drug administration. However, the barrier properties of the outermost layer, the stratum corneum, have limited the number of successful transdermal dosage forms developed thus far. One of the strategies for overcoming this problem is temporary local reduction of the barrier function of the stratum corneum with the aid of a percutaneous absorption enhancer. Sucrose fatty acid esters (sugar ester...

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