نتایج جستجو برای: peripheral dose distribution
تعداد نتایج: 1070220 فیلتر نتایج به سال:
In radiotherapy practice, one often needs to compare two dose distributions. Especially with the wide clinical implementation of intensity-modulated radiation therapy, software tools for quantitative dose (or fluence) distribution comparison are required for patient-specific quality assurance. Dose distribution comparison is not a trivial task since it has to be performed in both dose and spati...
A Phase I dose escalation and pharmacokinetic study of the alkylating cytotoxic agent treosulfan was conducted to evaluate the maximum tolerated dose and the dose-limiting toxicities in patients with advanced malignancies rescued by autologous peripheral blood stem cell transplantation. Twenty-two patients (15 ovarian and 7 other carcinomas/lymphomas) with a median age of 48 years were treated ...
chlorotoxin is a 36 amino acids peptide, which is able to block chloride channels isolated from mouse brain. a derivative of chlorotoxin is synthesized and it is labeled by iodine 131; then animal experiments carry out on rats. multiple organ doses may be calculated with biological distribution results in rats with labeled compounds using simulated mcnp4c code. human dose can be calculated usin...
Chemotherapy-induced peripheral neuropathy (CIPN) is a well-documented toxicity leading to dose limitation. Ibrutinib an oral Bruton’s Tyrosine Kinase (BTK) inhibitor approved for treating chronic lymphocytic lymphoma. The most common neurological side effects of include headache and dizziness. Herein, we report as dose-limiting manifestation treatment.
Multiple mechanisms of drug resistance contribute to treatment failure. Although high-dose therapy attempts to overwhelm these defenses pharmacologically, this approach is only successful in a fraction of treated patients. Many drug resistance mechanisms are shared between malignant and normal cells, but the expression of various drug resistance mechanisms associated with hypoxia is largely con...
introduction: gafchromic ebt films are one of the self-developing and modern films commercially available for dosimetric verification of treatment planning systems (tpss). their high spatial resolution, low energy dependence and near-tissue equivalence make them suitable for verification of dose distributions in radiation therapy. this study was designed to evaluate the dosimetric parameters of...
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