Endometriosis is a debilitating, estrogen-dependent, progesterone-resistant, inflammatory gynecological disease of reproductive age women. Two major clinical symptoms of endometriosis are chronic intolerable pelvic pain and subfertility or infertility, which profoundly affect the quality of life in women. Current hormonal therapies to induce a hypoestrogenic state are unsuccessful because of un...

background: despite a high prevalence of endometriosis, there still exist many challenges in diagnosing the disease. this study aims to evaluate non-invasive and practical diagnostic methods by measuring serum and peritoneal fluid ca 125 levels in patients with endometriosis. a secondary aim is to determine the correlation between these markers with the stage of disease as well as the relations...

STUDY QUESTION Are protein oxidative stress markers [thiols, advanced oxidation protein products (AOPP), protein carbonyls and nitrates/nitrites] in perioperative peritoneal fluid higher in women with histologically proven endometriosis when compared with endometriosis-free controls? SUMMARY ANSWER Protein oxidative stress markers are significantly increased in peritoneal fluids from women wi...

BACKGROUND Interleukin 33 (IL-33) is a cytokine involved in fibrotic disorders. We have analyzed IL-33 levels in the sera and peritoneal fluids of women with various forms of endometriosis and investigated the correlation with disease activity. METHODS We conducted a prospective laboratory study in a tertiary-care university hospital between January 2005 and December 2010. Five hundred and te...

CONTEXT Endometriosis is characterized by the growth of ectopic endometrial tissue. Nerve fibers are frequently associated with ectopic lesions, and neurogenic inflammation may play a role in endometriosis. OBJECTIVE The purpose of this study was to determine the presence of tachykinin receptors in endometriotic lesions and the role of TNFα on their expression. DESIGN This study was an asse...

Endometriosis is a chronic condition characterized by the presence of abnormal endometrial tissue outside uterus. These misplaced cells are responsible for inflammation, symptoms, scar and adhesions. manifests mainly in three patterns: superficial peritoneal lesions (SUP), ovarian endometriomas (OMA) deep infiltrating endometriosis (DIE). It also exhibits atypical extremely rare localization. T...

OBJECTIVE Endometriosis is characterized by the ectopic growth of endometrial tissue. One of the first steps to the spread of endometriosis in the peritoneal cavity is the attachment of endometriotic cells to peritoneal surfaces after they have been released into the peritoneal fluid from pre-existing endometriotic lesions. The increased adhesive and proliferative potential of endometriotic cel...

Endometriosis is a common gynaecological disease associated with pelvic pain and infertility. Current treatments include oral contraceptives combined with nonsteroidal anti-inflammatory drugs or surgery to remove lesions, all of which provide a temporary but not complete cure. Here we identify an endometriosis-targeting peptide that is internalized by cells, designated z13, using phage display....

Endometriosis, defined as growth of the endometrial cells outside the uterus, is an inflammatory disorder that is associated with chronic pelvic pain and infertility in women of childbearing age. Although the estrogen-dependence of endometriosis is well known, the role of progesterone in development of this disease remains poorly understood. In this study, we developed a disease model in which ...

Advances in preoperative diagnostics as well surgical techniques for the treatment of endometriosis, especially deep call a classification system, that includes all aspects disease such peritoneal ovarian and secondary adhesions. The widely accepted revised American Society Reproductive Medicine (rASRM) has certain limitations because its incomplete description endometriosis. In contrast, Enzia...