Postprandial hypoglycemia is a syndrome secondary to disorders in which hypoglycemia is manifested within 5 hours after a meal (1). It is classified into two types depending on the time of occurrence, i.e., ‘early,’ with onset within 2 hours, and ‘late,’ occurring between 3 and 5 hours after a meal. The early variety is thought to be secondary to abnormally rapid gastric emptying, whereas late ...

Glucose is the predominant source of energy for the fetal and neonatal brain. During the process of adaptation from a continuous supply of glucose in-utero to an intermittent supply after birth, the neonate is prone to periods of low blood glucose. Transient mild decreases in blood glucose levels are a common feature of perinatal adaptation. This period is characterized by an up-regulation of h...

Nesidioblastosis is a rare cause of hyperinsulinemic hypoglycemia in adults. We report a case of combined hypopituitarism with secondary adrenal insufficiency and nesidioblastosis with symptomatic hypoglycemia. This 84-year-old woman had a diagnosis of right side orbital lymphoma and underwent one complete course of local radiotherapy 6 months prior to this admission. Intermittent consciousness...

Objective. Noninsulinoma pancreatogenous hypoglycemia syndrome (NIPHS) is a disorder of endogenous hyperinsulinemia that is clinically distinguishable from insulinoma, with a greater preponderance after Roux-en-Y gastric bypass (RYBG). Hyperinsulinemic hypoglycemia can predispose to attenuation of counterregulatory hormone responses to hypoglycemia, and consequent suppression of the hypothalami...

Leptin, an adipocyte-derived factor, has multiple biological roles including mitogenesis. We investigated the effect of normal development, acute and chronic hyperglycemia and hypoglycemia, and selective acute hyperglycemia, or hyperinsulinemia, on fetal ovine white adipose tissue (WAT) leptin mRNA concentrations. Leptin mRNA amounts expressed as a ratio to the internal control ribosomal S2 mRN...

Insulinoma is a rare, usually benign, pancreatic neuroendocrine tumor. The clinical features of an insulinoma are fasting hypoglycemia with neuroglycopenic symptoms including confusion and unusual behavior, while hypertension is usually not associated with the disease. We herein report a patient with insulinoma who manifested paroxysmal hypertension and neuroglycopenic symptoms. The possible et...

Insulin resistance and abnormal carbohydrate metabolism is a recognized complication in patients with advanced chronic kidney disease. We describe a rare case of severe hypoglycemia with inappropriate endogenous hyperinsulinemia in a hemodialysis patient following parathyroidectomy for severe secondary hyperparathyroidism. The patient required intravenous dextrose infusions for 3 days to preven...

OBJECTIVE Higher insulin levels during an oral glucose test (OGTT) have been shown in South Asians. We aimed to investigate if this increased insulin response causes reactive hypoglycemia later on, and if an increased glucagon-like-peptide-1 (GLP-1) response, which could contribute to the hyperinsulinemia, is present in this ethnic group. METHODS A prolonged, 6-h, 75-g OGTT was performed in h...