background: immunization against diphtheria, tetanus and pertussis has been applied in iran since 1950. who suggests periodical evaluation of effectiveness of the triple diphtheria-tetanus-whole cell pertussis (dtwp) vaccine, worldwide. objectives: to determine the immunogenicity of locally manufactured dtwp vaccine administered to preschool children in a number of health centers of tehran in 2...

background: bordetella pertussis is the causative agent of pertussis. in brazil, laboratory diagnosis of pertussis is based on the culture. in 2010, was standardized the real-time pcr taqman® in routine diagnosis. objectives: the aim of this study was to evaluate the impact achieved with the introduction of rt-pcr for the routine diagnosis of pertussis and to compare with the results obtained f...

background: the increasing incidence of pertussis among adolescents and adults in recent years is an alarming factor in transmission of the infection to non-immune infants and children. vaccination of pregnant women, immediately after delivery and before being discharged from the hospital may help to protect mothers and their newborns against the disease. decision making process, regarding mate...

Considering the circulation of Bordetella pertussis clinical strains among populations with high vaccination coverage, it is necessary to have a proper understanding of this bacterium causing whooping cough. Various techniques, which are available for studying B. pertussis, can facilitate a proper comparison between different populations. We genotypically analyzed a collection of two vaccine st...

The transmission dynamics of a pertussis-pneumonia co-infection model is analyzed. takes into account temporary immunity infected infants and includes maternally derived compartment. basic reproduction number the co-infected obtained using next generation matrix, stability analysis carried out. exhibits four equilibria, namely, pertussis-free equilibrium, pneumonia-free co-infection-free equili...

Abstract Bordetella pertussis is the causative agent of whooping cough. The transition from whole cell (wP) to acellular vaccines (aPs) triggered an increase in incidence despite wide-spread vaccine coverage. aPs contain protein antigens purified B. pertussis: pertactin, fimbriae, filamentous hemagglutinin (FHA), and toxin (PT). Antibodies are critical for protection against pertussis, have bee...

Pertussis, mainly caused by Bordetella pertussis, is a severe respiratory disease that can be fatal, especially in young infants. Vaccines, massively implemented since the middle of last century, have substantially reduced pertussis incidence, but not been able to fully control disease. One shortcomings current vaccines their inability prevent infection and transmission B. contrast immunity fol...

Background and aim Pertussis risk increases during pregnancy when it can be passed from an infected, non-vaccinated mother to the newborn. The pertussis vaccine, Boostrix (Tdap: tetanus, diphtheria, pertussis), was approved by U.S. Food Drug Administration (FDA) for immunization of pregnant women third trimester. current cross-sectional study aimed assess awareness level towards pertussis. Meth...

Abstract Background The incidence of pertussis shows an increasing trend in recent years, but some clinicians often lack sufficient understanding the clinical characteristics and risk factors for severe pertussis, more effective measures should be taken to reduce mortality young infants Methods A retrospective study was conducted, 184 children with who had been hospitalized Department Pediatric...