A novel pestivirus species was discovered in a piglet-producing farm in Austria during virologic examinations of congenital tremor cases. The emergence of this novel pestivirus species, provisionally termed Linda virus, in domestic pigs may have implications for classical swine fever virus surveillance and porcine health management.

A disease survey was conducted between 2014 and 2018 in the Polish goat population to determine seroprevalence of pestiviral infection. Blood samples from 910 goats (782 females 128 males) were collected 62 herds tested for bovine viral diarrhea virus (BVDV) infection with a competitive ELISA serial fashion. Between 10 13 adult female randomly selected each herd, assuming individual-level herd ...

Peptides deduced from the C-terminal end (residues 191 to 227) of pestivirus envelope protein E were used to develop enzyme-linked immunosorbent assays (ELISAs) to measure specifically antibodies against different types of pestiviruses. The choice of the peptide was based on the modular structure of the E protein, and the peptide was selected for its probable independent folding and good exposu...

Bovine viral diarrhoea virus (BVDV) is an endemic pathogen worldwide and eradication strategies focus on the identification and removal of persistently infected (PI) animals arising after in utero infection. Despite this, acute infections with BVDV can persist for months or years after the removal of the PI source despite repeated screening for PIs and tight biosecurity measures. Recent evidenc...

Wild boar are an important reservoir of Classical swine fever virus (CSFV) in several European countries, where most of the primary outbreaks in domestic pigs are directly related to the endemic disease situation in the wild boar population. Oral immunisation has been introduced as an additional control measure to accelerate CSF eradication in wild boar in Germany since 1993. Immunisation with ...

The purpose of this study was to investigate whether sheep grazing communal alpine pastures with cattle can transmit Border disease virus (BDV) to cattle. A total of 1170 sheep and 923 cattle were tested for BDV using RT-PCR (sheep) and for pestivirus antibodies using an ELISA (cattle), respectively, before being moved to one of 4 pastures (A, B, C and D). Eight sheep from pasture C were viraem...

Pestiviruses express their genome as a single polypeptide that is subsequently cleaved into individual proteins by host- and virus-encoded proteases. The pestivirus N-terminal protease (N(pro)) is a cysteine autoprotease that cleaves between its own C-terminus and the N-terminus of the core protein. Due to its unique sequence and catalytic site, it forms its own cysteine protease family C53. Af...

Serological survey on the occurrence of alpha-herpesvirus and pestivirus infections in the population of European bison in the Bialowieza Primeval Forest was conducted. Sera from 40 randomly selected individuals were tested using two commercial IDEXX ELISA tests. The study design allowed excluding or confirming the infection with the probability of 95% and at the expected prevalence of 30%. No ...

We oVer the hypothesis that some forms of cerebral white matter damage (WMD) in preterm neonates might be caused by transplacental viral infection of the fetus during the first or second trimester of pregnancy. Potts and colleagues speculated on the possible role of a human pestivirus (PV) in the aetiology of congenital microcephaly. We suggest PV might be a candidate virus for some form of WMD...