BACKGROUND Periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome is the most common cause of periodic fever in childhood. This study aimed to investigate sleep patterns possible factors that are associated with disturbances among children PFAPA syndrome. METHODS Sixty-two patients 68 age sex matched healthy controls were enrolled study. Patients who had an attack during...

Results Coexistence of FMF and PFAPA was in 10 out of 28 patients (36%). They had earlier FMF onset (mean age of 1y. 3 mo.), frequent febrile attacks of abdominal pain and/or pleuritis, pericarditis (7 out of 10 patients), aphthous stomatitis (6 patients), tonsillitis with cervical lymphadenitis (9 children), as well as marked increase of acute inflammatory markers. An average age of PFAPA mani...

PFAPA syndrome is characterized by periodic episodes of high fever, aphthous stomatitis, pharyngitis, and/or cervical adenitis. It is of unknown etiology and manifests usually before 5 years of age. We determined serum and intracellular cytokine levels in six PFAPA patients (4 males, 2 females, mean age 8 years (+/- 1.2 SEM), range 4-13) during the symptom-free period as well as 6-12 hours and ...

Among 40 children undergoing tonsillectomy for recurrent pharyngitis, 15 (37.5%) had presented preoperatively with complaints compatible with PFAPA syndrome. All 15 had had periodic fever every three to four weeks and pharyngitis; 12 (80%) had cervical adenitis and five (33%) aphthous stomatitis. All children had been well between episodes and showed a dramatic postoperative improvement. PFAPA ...

Familial Mediterranean fever (FMF) can be classified into typical and incomplete/atypical types. An accompanying of severe abdominal pain by the serotitis is characteristic of typical FMF. Periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) syndrome-like symptoms has been found in atypical type carrying P369SR408Q mutations in the responsible gene MEFV. FMF with both sym...

UNLABELLED There have been remarkable developments in the field of autoinflammatory diseases over the last 20 years. Research has led to definitions of new conditions, increased understanding of disease mechanisms and specific treatment. The polygenic autoinflammatory condition of periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) is the most common autoinflammatory ...

OBJECTIVES The aims of this study were to describe the clinical features of periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) and identify distinct phenotypes in a large cohort of patients from different countries. METHODS We established a web-based multicentre cohort through an international collaboration within the periodic fevers working party of the Pediatric ...

Periodic fever syndromes are a group of diseases characterized by episodes of fever with healthy intervals between febrile episodes. The first manifestation of these disorders are present in childhood and adolescence, but infrequently it may be presented in young and middle ages. Genetic base has been known for all types of periodic fever syndromes except periodic fever, aphthous stomatitis, ph...

Characteristic feature of PFAPA syndrome is periodic episodes of fever recurring in 21-28 days in infants and young children. Fever is accompanied by aphtosus stomatitis, pharyngitis and cervical adenopathy. Diagnosis of this syndrome are based on typical clinical manifestations, because there are no characteristic changes in laboratory findings. The reason of this syndrome is unknown. We descr...

Introduction and purpose: Periodic fever, aphthous stomatitis, pharyngitis, adenitis (PFAPA syndrome) is the most common periodic fever condition in child age. Discussed syndrome generally a self-limited condition, but it can significantly decrease quality of child’s life. It be also challenge for parents, as well medical professionals. Knowledge very important among many specialists because ea...