Higher environmental temperature is one of the major factors responsible for reduced fertility in farm animals. Heat stress causes a great suppression in endometrial function [1] besides compromised follicular growth [2], embryonic function [3] and oocyte developmental potential [4]. Heat stress also increases the production of PGF2α in the endometrium, leading to the early regression of CL or ...

Luteinized unruptured follicle (LUF) syndrome is a recurrent anovulatory dysfunction that affects up to 23% of women with normal menstrual cycles and up to 73% with endometriosis. Mechanisms underlying the development of LUF syndrome in mares were studied to provide a potential model for human anovulation. The effect of extended increase in circulating LH achieved by administration of recombina...

In this study, we aimed to investigate reproductive performance in estrus-induced Zandi ewes treated with equine chorionic gonadotrophin (eCG) injection in combination with prostaglandin F2α (PGF2α)and gonadotrophin releasing hormone (GnRH) during non-breeding season. The estrous cycle was synchronized using controlled internal drug release (CIDR) for 12 days. The ewes were randomly assigned to...

Dairy cows that are being cared for in family businesses were used to compare the pregnancy rates by applying different time periods, using progesterone devices, and fixed-time artificial inseminations. The randomly divided into 3 groups. Group 1(n = 56); On day 0, GnRH (IM) (10mg Buserelin acetate, Ovarelin, CEVA DIF) + Progesterone implants (PRID®) (1,55 g CEVA), Day 8 PGF2α (Dinoprost tromet...

Background and Aim: Oxidative stress, caused by environmental insults, may interfere with redox signaling during pregnancy is a known contributor to preterm birth. In vivo in vitro studies indicate that PFAS generate reactive oxygen species, but this has been minimally investigated humans not examined pregnancy. We the effects of prenatal exposure on oxidative stress biomarkers, hypothesizing w...

To evaluate the effect of intrauterine cephapirin on treatment of endometritis 39 Holstein dairy cows that affected with postpartum endometritis were selected and randomly assigned to two experimental designs. In experiment 1, 6 out of 14 cows were 25 to 30 days after parturition were treated by intrauterine oxytetracycline. Another 8 cows were treated by intrauterine cephapirin (Metri-Care). I...

Pulsatile release of uterine prostaglandin F2α(PGF2α) induces luteolysis in ruminants. However, the mechanism(s) that initiates and maintains luteolysis has not been defined. The present study tested the hypothesis that the endogenous PGF2α pulse generator is uterine-derived platelet-activating factor (PAF). Ovariectomized ewes were given exogenous progesterone (P), estradiol (E), or both (P+E,...

Many estrus synchronization protocols aim to induce a new follicular wave to improve response and enhance pregnancy rate. Our objectives were to determine the effectiveness of GnRH analog administered d 0 and 9 during an extended controlled internal drug release (CIDR) protocol to produce 2 follicular waves, induce cyclicity in anestrus cows, and evaluate the effi cacy of a single 50-mg dose of...

In China, escin has been widely used in the clinic as a potent anti-inflammatory drug. Previous studies have indicated that escin exerts its anti-inflammatory effect by enhancing the release of glucocorticoids (GCs) and prostaglandin-F2α (PGF2α), and this has been documented in the drug description. However, our previous studies demonstrated that escin did not increase the secretion of GCs, but...

Consequences of primary dsysmenorrhea (PD) can be severe. Increased prostaglandin production leads to uterine contraction and insufficient blood flow to the endometrium causing ischemia and pain symptoms. Protein tyrosine kinase/phosphatase activities contribute to the modulation of uterine contraction. In our previous study, we found the synthetic β-methoxyacrylates compound Fluacrypyrim (FAPM...