iii To mankind and science iv ACKNOWLEDGEMENTS I am especially indebted to my academic advisor, Dr. Constantin F. Aliferis. Without his colossal commitment and contribution to this project, this work would probably never exist. I would also like to acknowledge members of my Ph. Statnikova, and my mother-in-law, Ludmila Morozyuk. Their encouragement and support were crucial for my Ph.D. studies ...

ii To my family. iii ACKNOWLEDGEMENTS I would like to thank all those who helped me in completing this dissertation. Most and foremost, Karem Sakallah, who has been an outstanding academic advisor and a very good friend for the course of my graduate work at Michigan. His suggestions, thorough reviews, and encouragement at the various stages of my Ph.D research are gratefully acknowledged. Many ...

Esophageal pH monitoring is considered the gold standard for the diagnosis of gastroesophageal reflux disease because of the normal ranges across the pediatric age range. However, this method can only detect acid reflux. Multichannel intraluminal impedance-pH (MII-pH) monitoring has recently been used for the detection of bolus reflux in infants and children. This method allows for the detectio...

In this essay I analyze Einstein’s statistical papers from 1902–1904. In these papers, Einstein developed the foundations of a theoretical program that he applied to concrete problems in 1905 and in subsequent years. It combined skepticism about classical mechanics, a firm belief in molecules, and absolute confidence in statistical principles. However, Einstein’s dissertation does not follow hi...

We consider a PH/PH/1 queue in which a threshold policy determines the stage of the system. The arrival and service processes follow a Phase-Type (PH) distribution depending on the stage of the system. Each stage has both a lower and an upper threshold at which the stage of the system changes, and a new stage is chosen according to a prescribed distribution. The PH/PH/1 multi-threshold queue is...

Front-side connected, N-channel, normally-off, chemical field effect transistor (ChemFET) microsensors including a SiO2/Si3N4 pH-sensitive gate have been fabricated using a standard P-well silicon technology. The fabrication and packaging processes are described and sensor properties and performances are demonstrated through pHmeasurements. Finally, the front-side connected ChemFETs microsensor...