Aims The X-ray micro-tomography (micro-CT) technique has been used to visualize the microstructure of pharmaceutical granules produced by high shear wet granulation and the dynamic evolution of porosity during granule dissolution. The combination of time-resolved micro-CT imaging with UV/VIS detection of the quantity dissolved made it possible to evaluate the effective diffusion coefficient of ...

This study reported that the sample used in was an infusion using fresh coriander leaves samples taken Lubuk Pakam area. Several studies have shown active components of seeds are essential oils such as sabiene, myrcene, alphaterpine, ocimene, linalool, graniol, decanal, desilaldehyde, trantridecen, petroselinic acid, octadesenic d-mannite, scopoletin, psimena, kamfena and felandren. These cause...

Introduction: Poor aqueous solubility of an active pharmaceutical ingredient (API) is one of the most pressing problems in pharmaceutical R&D, with as many as 90% of new API candidates in this category (Lobmann et al., 2013). Dissolution rate in the gastrointestinal tract is the rate limiting factor for the absorption of many of these drugs (Zimmermann et al., 2009), which may limit their bioav...

Increasingly, poorly soluble drug candidates are entering development, which has made identifying and selecting stable solid forms of an active pharmaceutical ingredient (API) with enhanced in vivo absorption more difficult. While pharmaceutical salts are the most common choice for solid forms, cocrystals are also known to improve “druggability” characteristics such as solubility, dissolution, ...

The governments of many countries strongly support the production and clinical use of generic medicinal products which are “copies” of patented drugs and can be marked at lower cost. At present time bioequivalence testing is regarded as a useful methodology to perform comparisons among different products containing the same active ingredient. This report presents the results of comparative bioe...

The inhalational drug market, especially the generic market, has a tremendous growth potential globally (GBI Research, 2011; Espicom, 2013; Transperancy: Market Research, 2013). Generics are drugs that are bioequivalent to the approved drugs. The United States Food and Drug Administration (FDA) has defined bioequivalence as (U.S. FDA, 2014), “The absence of a significant difference in the rate ...