The greater consciousness awakened in recent years on healthy and organic has led to increase “natural” products demand worldwide. The quality and high content on bioactive compounds have consolidated their penetration in cosmetic and food market, showing great potential within the pharmaceutical sector too. For this reason, food, cosmetic and pharmaceutical sectors have been forced to develop ...

An investigation into the comparative reactivity of simple β-lactones and β-thiolactones toward a thiol and a primary amine is reported. A simple 3-mercaptomethyl-2-oxetanone is found to undergo rearrangement in the presence of aqueous base to give the corresponding thietane-3-carboxylic acid rather than the 3-hydroxymethyl-2-thietanone. Implications for the use of β-thiolactones in bioorganic ...

Recently, heterocyclic compounds analogues and their derivatives have attracted strong interest in medicinal chemistry due to their biological and pharmacological properties. The small and simple thiadiazole nucleus possesses numerous biological properties like antitumor, antimicrobial, anti-inflammatory, anticonvulsant, and antidiabetic activities. These activities are also possessed by its su...

Pharmaceutical drugs play an important role in human life since they caused a revolution in human health. Notably, their administration to a living organism helps body to stay healthy. Commonly, they are employed to diagnose, prevent, or treat and cure a disease via a biological effect on a human body. Administration of impurity-free and adequate amounts of pharmaceut...

There is a rapid increase in the demand for natural hypopigmenting agents from marine sources for cosmeceutical and pharmaceutical applications. Currently, marine macroalgae are considered as a safe and effective source of diverse bioactive compounds. Many research groups are exploring marine macroalgae to discover and characterize novel compounds for cosmeceutical, nutraceutical, and pharmaceu...

Provided herein are novel nitrogen-containing 2,3-dihydroquinazolinone compounds as Nav1.8 inhibitors, pharmaceutical compositions, use of such in treating pain and cardiovascular diseases, processes for preparing compounds.

The oral delivery of lipophilic drugs presents a major challenge because of the low aqueous solubility of such compounds. Selfmicroemulsifying drug delivery systems (SMEDDSs) have gained exposure for their ability to increase solubility and bioavailability of poorly soluble drugs. SMEDDS, which are isotropic mixtures of oils, surfactants, solvents and co-solvents/surfactants, can be used for th...