A simple, sensitive and economically viable spectrophotometric method for the determination of corticosteroids (predinsolone {PSL}, dexamethasone {DEX}, prednisone {PS}, betamethasone sodium phosphate {BEP} and hydrocortisone {HYD} has been developed. The method involves the oxidation of corticosteroids by iron (III) and subsequent complexation of iron (II) with potassium hexacynoferrate (III),...

conclusions according to release exponent n > 1, diffusion mechanism is super case п. the prepared micronized benzoyl peroxide in foamable formulation was stable according to different pharmaceutical evaluation. the emu oil incorporated in this formulation could reduce drawback of bpo (benzoyl peroxide). this formulation could be a good candidate in acne treatment. objectives benzoyl peroxide f...

Introduction: In vitro drug release and dissolution testing play an important role in pharmaceutical formulation development and quality control. Poorly soluble candidate molecules constitute a major challenge for the formulation development since the insufficient solubility causes problems for in vitro and in vivo assays, with consequent increased risk of attrition and costs (Di et al., 2012),...

one of the most significant issues in pharmaceutical industries, prior to commercializationof a pharmaceutical preparation is the “preformulation” stage. however, far too attention hasbeen paid to verification of the software assisted statistical designs in preformulation studies.the main aim of this study was to report a step by step preformulation approach for a semisolidpreparation based on ...

A simple, rapid, sensitive and precise UV spectrophotometric method have been developed for the estimation of carbocisteine from bulk drug and pharmaceutical formulation. In this method carbocisteine showed maximum absorbance at about 200.4 nm in 0.1N HCl. Beer’s law was followed in the concentration range of 10 to 140 μg/ ml. Regression equation was found to be y = 0.0067 x – 0.0015 and coeffi...

Received; August 4, 2005, Accepted; November 5, 2005 *To whom correspondence should be addressed : Hiroshi ARAYA, Formulation Technology Research Department, Pharmaceutical Technology Division, Chugai pharmaceutical Co., Ltd., 5-1, Ukima 5-chome, Kita-ku, Tokyo, 115-8543 Japan. Tel. +81-3-3968-4383, Fax. +81-3-39684810, E-mail: [email protected] Drug Metab. Pharmacokinet. 21 (1): 45–5...