The cytochrome P450 (CYP) mixed-function monooxygenases are located on the smooth endoplasmic reticulum of cells throughout the body, primarily in liver and small intestine. These enzymes are responsible for the oxidative (Phase I) metabolism of a wide number of compounds, including many medications. In recent years, interest in these enzymes has exploded as their role in drug interactions, dru...

schizophrenia is a debilitating illness, rating as one of the leading causes of lost years of quality of life. the illness imposes a disproportionate burden on patients and their families, healthcare systems and society. pharmacological management is the cornerstone of treatment of schizophrenia, and antipsychotics, both first generation of antipsychotics and second generation of antipsychotics...

The purpose of this meta-analysis was to examine rates of treatment refusal and premature termination for pharmacotherapy alone, psychotherapy alone, pharmacotherapy plus psychotherapy, and psychotherapy plus pill placebo treatments. A systematic review of the literature resulted in 186 comparative trials that included a report of treatment refusal and/or premature termination for at least 2 of...