The cross talk between the over expression of oxygen-free radicals is known as reactive oxygen species (ROS) that is associated with the excessive telomerase activity (TA). Telomerase activity is an invariable finding where human telomerase (hTERT) has been implicated in tumor oxidative stress and redox-mediated malignancy. The hTERT over expression is a novel tumor marker and is promising as a...

Step polymerization of Bisphenol-A diphthalic anhydride (BAPA) with various mixtures from m-phenylene diamine (m-PDA) and 2-(perfluorohexylmethyl)butan-1,4-diamine (TFD) led to hydrophobic copolyetherimides bearing RF = -CH2-C6F13 side chains that were characterized by NMR, elementary analysis, DSC, TGA and surface energy analysis. By increasing the TFD unit %, the glass transition temperature ...

The respiratory components of the envelope membrane preparation of Neisseria meningitidis were investigated. Oxidase activities were demonstrated in this fraction in the presence of succinic acid, reduced nicotinamide adenine dinucleotide, and ascorbate-N,N,N',N'-tetramethyl-p-phenylene-diamine (TMPD). Differences in the kinetics of inhibition by terminal oxidase inhibitors on the three oxidase...

We aimed to characterize the role of NAD(P)H:quinone oxidoreductase (NQO1) in apoptosis induction by antitumour quinones RH1 (2,5-diaziridinyl-3-hydroxymethyl-6-methyl-1,4-benzoquinone) and MeDZQ (2,5-dimethyl-3,6-diaziridinyl-1,4-benzoquinone). Digitonin-permeabilized FLK cells catalyzed NADPH-dependent single- and two-electron reduction of RH1 and MeDZQ. At equitoxic concentrations, RH1 and M...

p-N,N-dimethyl phenylene diamine(DMPD) is oxidized with Iodine into p-N,N-dimehylbenzoquinonemonoimine which can form a purple –red charge –transfer complex with aromatic primary amine (APA) at pH 3.0 . The absorbance of the p-N,Ndimehylbenzoquinonemonoimine – APA charge-transfer complex is measured at 520nm. This proposed method is simple, rapid and sensitive with reasonable precision and accu...

The colorimetric identification of pathogenic and non-pathogenic bacteria in cell culture is commonly performed using the redox mediator N,N,N',N'-tetramethyl-para-phenylene-diamine (TMPD) in the so-called oxidase test, which indicates the presence of bacterial cytochrome c oxidases. The presented study demonstrates the ability of electrochemistry to employ TMPD to detect bacteria and quantify ...

The colorimetric identification of pathogenic and non-pathogenic bacteria in cell culture is commonly performed using the redox mediator N,N,N0,N0-tetramethyl-para-phenylene-diamine (TMPD) in the socalled oxidase test, which indicates the presence of bacterial cytochrome c oxidases. The presented study demonstrates the ability of electrochemistry to employ TMPD to detect bacteria and quantify t...

A photoreactive derivative of a tetradecapeptide G-protein activator (peptide Q) derived from the alpha 2-adrenergic receptor was designed and used to label purified G-protein (Go/Gi). N-bromoacetyl-N'-(3-diazopyruvoyl)-m-phenylene-diamine (Br-DAP) was conjugated to the C-terminal cysteine of peptide Q. The DAP-modified peptide Q (DAP-Q) specifically incorporated into the a subunit of Go. The i...

A series of Schiff bases such as 2-(substituted phenylimino) quinoxaline-3-one were synthesized by nucleophilic addition reaction of quinoxaline-2,3-dione with p-Phenylene diamine followed by the Schiff reaction using different aldehydes in alcholol. A total of five compounds were synthesized by both conventional and microwave oven method with good percentage yield. They were purified and chara...