BACKGROUND AND PURPOSE Some commonly used anorexiants, including methamphetamine and phenylpropanolamine, have been associated with stroke. Because phentermine is an anorexiant with a chemical structure similar to that of amphetamines, similar side effects might be expected. CASE DESCRIPTIONS Two patients using phentermine (one was also using phendimetrazine) developed ischemic cerebrovascula...

Phenylpropanolamine (PPA) is a drug that has been associated with serious side effects including stroke. It is often combined with caffeine in diet preparations and "look-alike" pills. In order to determine if PPA/caffeine can lead to stroke in normotensive and/or hypertensive rats, we administered the combination in six times the allowed human dose calculated on a per weight basis for the rats...

35. Wessler S, Gitel SN: Warfarin: From bedside to bench. New Engl J Med 311: 645-652, 1984 36. HullR, HirshJ, Jay R.etah Different intensities of oral anticoagulant therapy in the treatment of proximal-vein thrombosis. New Engl J Med 307: 1676-1681, 1982 37. Barron KD, Fergusson G: Intracranial hemorrhage as a complication of anticoagulant therapy. Neurology 9: 447-455, 1959 38. Iizuka J: Intr...

The Parahippocampal Place Area (PPA; Epstein & Kanwisher, 1998) is a region within posterior parahippocampal cortex that responds selectively to visual stimuli that convey information about the layout of local space. Here we describe two patients who suffered damage to the PPA after vascular incidents. Both subsequently exhibited memory problems for topographical materials and were unable to na...

Coexistence of thyrotoxicosis and moyamoya disease is extremely rare. A 23-year-old woman who had a history of migraine, suffered from frequent right carotid transient ischemic attacks, followed by an ischemic stroke after taking ergotamine for migraine. Magnetic resonance angiography revealed a tubular stenosis of the right internal carotid artery (ICA) and bilateral strictures of the supracli...