PURPOSE To report that acute phenytoin toxicity may result in acute visual dysfunction. METHODS A 19-year old man with cryptogenic simple partial and secondary generalized epilepsy developed blurred vision and xanthopsia after phenytoin loading for status epilepticus. Color blindness was found on testing with Ishihara's pseudo-isochromatic charts and visual fields (Goldmann perimeter) showed ...

To evaluate the effect of phenytoin on burn wounds and to compare the effect of the combination of topical phenytoin preparation in dexamethasone treated burn wounds in rats, partial thickness thermal burn wounds were inflicted upon five groups of six rats each. Group I was assigned as control, Group II received the standard silver sulphadiazine, Group III was given topical phenytoin and Group ...

Abstract Background Phenytoin is a commonly used antiepileptic drug (AED) for postoperative seizure prophylaxis; it associated with adverse cardiovascular effects. Fosphenytoin considered safer alternative but can produce prolongation of QT interval. This hypothesis generating pilot study evaluated the changes in hemodynamics and heart rate corrected interval (QTc) phenytoin fosphenytoin during...

Accidental ingestion of phenytoin can lead to severe neurological sequelae. Charcoal hemoperfusion decreases phenytoin levels but has never been reported before in children. We present a child with accidental ingestion of phenytoin who responded to charcoal hemoperfusion.

AIMS Pharmacokinetic studies suggest that trimethoprim (TMP) can inhibit the hepatic metabolism of phenytoin, but the clinical relevance of this is uncertain. We studied the risk of phenytoin toxicity following the prescription of trimethoprim/sulfamethoxazole (TMP/SMX), a commonly used antibiotic, among elderly patients receiving phenytoin. METHODS We conducted a population-based, nested cas...

Despite the fact that the teratogenic effects of phenytoin have been suggested in several case reports, the evidence for a possible oncogenic potential of phenytoin has not been widely recognized. Recently, neuroblastoma as well as other neuroectodermal and non-ectodermal tumors has been seen in several children exposed to phenytoin prenatally. Previous cases have been almost uniformly associat...

Ambulant patients with recently diagnosed generalised or psychomotor seizure disorders or both were randomly assigned to two dosage regimens of phenytoin. Drug compliance was evaluated with subsequent blood phenytoin levels four to eight weeks after initial enrollment into the study. Although the two groups had similar mg-kg daily dosages of phenytoin, the mean blood levels were statistically d...

Though rare, long term use of phenytoin has been associated with various lymphatic system disorders like pseudolymphoma, Hodgkin lymphoma and non Hodgkin lymphoma. Histopathological changes in phenytoin induced lymphadenopathy may be heterogenous and non specific as well. Phenytoin induced pseudo lymphoma syndrome may show histopathological findings similar to mycosis fungoides and may take a p...

Serum phenytoin concentrations were monitored prospectively in 26 patients with previously untreated partial epilepsy, during monotherapy with phenytoin. Only six remained entirely seizure-free, although only four experienced further tonic-clonic seizures. There was no correlation between serum phenytoin concentrations and freedom from partial seizures in those patients in whom such seizures re...

purpose : studies show that phenytoin is effective in improvement of different chronic ulcers such as venous stasis ulcers, and diabetic ulcers. the exact mechanism is yet not clear investigators thought that phenytoin might help to heal intractable corneal ulcers by reducing inflammation, differentiating limbal fibroblasts, and promoting the invasion of the cornea with new blood vessels as sho...