Bone marrow fibrosis leading to dry tap aspiration and often associated with blast crisis has previously been reported in both Chronic myeloid leukemia Primary myelofibrosis. The similarities between these two conditions terms of clinical presentation morphology can really create a diagnostic dilemma. Here we present case 32 year old lady which closely resembled myelofibrosis transformation. Al...

The Philadelphia chromosome was the first specifıc karyotype abnormality associated with a particular neoplastic disease in humans. Ph translocation generats hybrid gene consisting of 5' exon sequences bcr on 22 fused to 3' exons and polyadenylation/termination ABL proto-oncogene from 9. molecular consequence this is transcription chimaeric m RNA transcribed novel 210 kd protein (p 210) CML, an...

Myeloproliferative neoplasms (MPNs) are traditionally separated into BCR-ABL-positive chronic myeloid leukemia (CML), and BCR-ABL-negative MPNs including primary myelofibrosis (PMF), essential thrombocythemia (ET), and so forth. One of the diagnostic requirements for PMF and ET is the absence of the Philadelphia chromosome, while its presence is almost universally indicative of CML. However, a ...

This report describes a case of lymphoid blast crisis of a chronic myelocytic leukemia with the occurrence of a double chromosomal population carrying a Philadelphia chromosome. Fifty-five % of the cells have 28 chromosomes, and 36% show the exact duplicate of the near haploid chromosome complement. The similarities between this near haploid cell line and those previously reported, as well as t...

Three patients had marked marrow fibrosis and an apparent Philadelphia (Ph) chromosome. Hematologic, cytogenetic, and molecular studies demonstrated the heterogeneity of such cases, including the first example of clinically typical myelofibrosis (MF) associated with a bcr gene rearrangement characteristic of chronic myelogenous leukemia (CML).